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  • Nylander, RutaUppsala universitet,Radiologi (author)

Relation between cardiovascular disease risk markers and brain infarcts detected by magnetic resonance imaging in an elderly population

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Elsevier BV,2015
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:du-16605
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-16605URI
  • https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.08.027DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-238456URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Established cardiovascular risk markers, such as hypertension, are associated with increased risk of brain infarcts. The newer markers N-terminal pro-brain natriuretic peptide, troponin I, C-reactive protein, and cystatin C may affect the risk of cardiovascular events and potentially, thereby, also stroke. We investigated the association between established and new risk markers for cardiovascular disease and brain infarcts detected by magnetic resonance imaging (MRI) at age 75.METHODS: Four hundred six randomly selected subjects from the Prospective Investigation of the Vasculature in Uppsala Seniors study were examined with MRI of the brain at age 75. Blood samples, measurements, and dedicated questionnaires at age 70 were used for analysis of risk markers. A history of diseases had been obtained at age 70 and 75. MRI was evaluated regarding lacunar and cortical infarcts. Univariate associations between outcomes and risk markers were assessed with logistic regression models.RESULTS: One or more infarcts were seen in 23% of the subjects (20% had only lacunar infarcts, 1% had only cortical infarcts, and 2% had both). Hypertension (odds ratio [OR] 2.6, 95% confidence interval [CI] 1.4, 4.7) and obesity (OR 1.3; CI 1.0, 1.8) were significantly associated with increased risk of brain infarction. The newer risk markers were not significantly associated with the brain infarcts.CONCLUSIONS: The new markers were not associated with the predominantly lacunar infarcts in our 75-year-old population, why troponin I and NT-proBNP may be associated mainly with cardioembolic infarcts as shown recently.

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  • Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
  • Wikström, JohanUppsala universitet,Radiologi(Swepub:uu)jwi06759 (author)
  • Lindahl, BertilUppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227 (author)
  • Venge, PerUppsala universitet,Biokemisk struktur och funktion(Swepub:uu)pervenge (author)
  • Larsson, AndersUppsala universitet,Biokemisk struktur och funktion(Swepub:uu)andlarss (author)
  • Ärnlöv, Johan,1970-Högskolan Dalarna,Medicinsk vetenskap,Uppsala universitet,Molekylär epidemiologi(Swepub:uu)johaarnl (author)
  • Berglund, LarsUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larsbelu (author)
  • Ahlström, HåkanUppsala universitet,Radiologi(Swepub:uu)hakanahl (author)
  • Larsson, Elna-MarieUppsala universitet,Radiologi(Swepub:uu)elnla305 (author)
  • Johansson, LarsUppsala universitet,Radiologi(Swepub:uu)larsjoha (author)
  • Uppsala universitetRadiologi (creator_code:org_t)

Related titles

  • In:Journal of Stroke & Cerebrovascular Diseases: Elsevier BV24:2, s. 312-3181052-30571532-8511

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