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Circulating alpha-t...
Circulating alpha-tocopherol and insulin sensitivity among older men with chronic kidney disease
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- Xu, Hong (author)
- Karolinska Institutet
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- Xiong, Zibo (author)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med & Baxter Novum, Stockholm, Sweden.;Peking Univ, Shenzhen Hosp, Div Nephrol, Shenzhen, Guangdong, Peoples R China.
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- Ärnlöv, Johan, 1970- (author)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Uppsala university,Kardiovaskulär epidemiologi,Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.
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- Qureshi, Abdul Rashid (author)
- Karolinska Institutet
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- Cederholm, Tommy (author)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism
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- Sjögren, Per (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Lindholm, Bengt (author)
- Karolinska Institutet
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- Riserus, Ulf (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Carrero, Juan Jesus (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med & Baxter Novum, Stockholm, Sweden;Peking Univ, Shenzhen Hosp, Div Nephrol, Shenzhen, Guangdong, Peoples R China. (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Journal of renal nutrition (Print). - : Elsevier BV. - 1051-2276 .- 1532-8503. ; 26:3, s. 177-182
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https://doi.org/10.1...
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Abstract
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- Objective: Insulin resistance is common in individuals with chronic kidney disease (CKD) and may be partly explained by modifiable risk factors. In the general population, vitamin E supplementation has been suggested to improve both insulin sensitivity and secretion. We here explore the potential role of vitamin E as a modifiable risk factor for insulin resistance among individuals with CKD.Design: Observational study.Setting: A total of 273 nondiabetic men aged 70 to 71 years with CKD defined as either cystatin C estimated glomerular filtration rate < 60 mL/minute/1.73 m2 or urinary albumin excretion rate ≥ 20 mg/minute from the third examination cycle of Uppsala Longitudinal Study of Adult Men.Subjects: A total of 273 nondiabetic men aged 70 to 71 years with CKD defined as either cystatin C estimated glomerular filtration rate < 60 mL/minute/1.73 m2 or urinary albumin excretion rate ≥ 20 μg/minute.Methods: Serum α-, β-, and γ-tocopherol concentrations were measured by high-performance liquid chromatography and expressed as μmol/total serum cholesterol and triglycerides (in mmol). Dietary vitamin E intake was estimated from 7-day food records.Main Outcome Measure: Insulin sensitivity index (M/I ratio) was measured by hyperinsulinemic-euglycemic glucose clamps. Univariate and multivariate regression models were fitted to assess the association between M/I and circulating concentrations of tocopherols.Results: The mean serum concentration of α-, β-, and γ- was 37.4 ± 6.58, 0.89 ± 0.23, and 4.32 ± 1.69 μmol/mmol, respectively. Median dietary vitamin E intake was 6.14 (interquartile range, 5.48-6.82) mg/day. In crude and fully-adjusted multivariate regression analyses, serum α-tocopherol levels were directly and strongly associated with M/I (standard β = 0.17, P = .003). No such association was observed for dietary vitamin E, serum β-, and γ-tocopherol concentrations.Conclusions: Serum α-tocopherol concentration associates with insulin sensitivity in nondiabetic older men with CKD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Hälsa och välfärd
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Xu, Hong
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Xiong, Zibo
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Ärnlöv, Johan, 1 ...
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Qureshi, Abdul R ...
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Cederholm, Tommy
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Sjögren, Per
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show more...
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Lindholm, Bengt
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Riserus, Ulf
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Carrero, Juan Je ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Journal of renal ...
- By the university
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Högskolan Dalarna
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Uppsala University
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Karolinska Institutet