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  • Carlsson, Axel C.Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi,Karolinska Institute, Sweden; Uppsala University, Sweden (author)

Association of soluble tumor necrosis factor receptors 1 and 2 with nephropathy, cardiovascular events, and total mortality in type 2 diabetes

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-02-29
  • Springer Science and Business Media LLC,2016
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:du-21191
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-21191URI
  • https://doi.org/10.1186/s12933-016-0359-8DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281234URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-126836URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133078156URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council; Swedish Heart-Lung foundation; Thureus foundation; Marianne and Marcus Wallenberg Foundation; Dalarna University; Uppsala University
  • AIMS/HYPOTHESIS: Soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2) contribute to experimental diabetic kidney disease, a condition with substantially increased cardiovascular risk when present in patients. Therefore, we aimed to explore the levels of sTNFRs, and their association with prevalent kidney disease, incident cardiovascular disease, and risk of mortality independently of baseline kidney function and microalbuminuria in a cohort of patients with type 2 diabetes. In pre-defined secondary analyses we also investigated whether the sTNFRs predict adverse outcome in the absence of diabetic kidney disease.METHODS: The CARDIPP study, a cohort study of 607 diabetes patients [mean age 61 years, 44 % women, 45 cardiovascular events (fatal/non-fatal myocardial infarction or stroke) and 44 deaths during follow-up (mean 7.6 years)] was used.RESULTS: Higher sTNFR1 and sTNFR2 were associated with higher odds of prevalent kidney disease [odd ratio (OR) per standard deviation (SD) increase 1.60, 95 % confidence interval (CI) 1.32-1.93, p < 0.001 and OR 1.54, 95 % CI 1.21-1.97, p = 0.001, respectively]. In Cox regression models adjusting for age, sex, glomerular filtration rate and urinary albumin/creatinine ratio, higher sTNFR1 and sTNFR2 predicted incident cardiovascular events [hazard ratio (HR) per SD increase, 1.66, 95 % CI 1.29-2.174, p < 0.001 and HR 1.47, 95 % CI 1.13-1.91, p = 0.004, respectively]. Results were similar in separate models with adjustments for inflammatory markers, HbA1c, or established cardiovascular risk factors, or when participants with diabetic kidney disease at baseline were excluded (p < 0.01 for all). Both sTNFRs were associated with mortality.CONCLUSIONS/INTERPRETATIONS: Higher circulating sTNFR1 and sTNFR2 are associated with diabetic kidney disease, and predicts incident cardiovascular disease and mortality independently of microalbuminuria and kidney function, even in those without kidney disease. Our findings support the clinical utility of sTNFRs as prognostic markers in type 2 diabetes.

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  • Östgren, Carl JohanLinköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Primärvården i västra länsdelen(Swepub:liu)caros18 (author)
  • Nyström, Fredrik HLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)freny92 (author)
  • Länne, TosteLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland(Swepub:liu)tosla34 (author)
  • Jennersjö, PärLinköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten(Swepub:liu)parje60 (author)
  • Larsson, AndersUppsala universitet,Biokemisk struktur och funktion,Uppsala University, Sweden(Swepub:uu)andlarss (author)
  • Ärnlöv, Johan,1970-Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Uppsala University, Sweden; Dalarna University, Falun, Sweden,Kardiovaskulär epidemiologi(Swepub:uu)johaarnl (author)
  • Uppsala universitetKardiovaskulär epidemiologi (creator_code:org_t)

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  • In:Cardiovascular Diabetology: Springer Science and Business Media LLC151475-2840

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