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Using proximity ext...
Using proximity extension proteomics assay to discover novel biomarkers associated with circulating leptin levels in patients with type 2 diabetes
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- Vavruch, Camilla (author)
- Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten
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- Nowak, C (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Rudholm Feldreich, Tobias (author)
- Högskolan Dalarna,Medicinsk vetenskap,Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.
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- Östgren, Carl Johan (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Vårdcentralen Ödeshög
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Söderberg, Stefan (author)
- Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, Sect Med, Umeå, Sweden.
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Nyström, Fredrik H (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Vårdcentralen Cityhälsan Centrum
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- Ärnlöv, Johan, 1970- (author)
- Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Family Med & Primary Care Unit, Huddinge, Sweden.;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.
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(creator_code:org_t)
- 2020-08-04
- 2020
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Abstract
Subject headings
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- We aimed to discover novel associations between leptin and circulating proteins which could link leptin to the development of cardiovascular disease in patients with type 2 diabetes (T2DM). In a discovery phase, we investigated associations between 88 plasma proteins, assessed with a proximity extension assay, and plasma leptin in a cohort of middle-aged patients with T2DM. Associations passing the significance threshold of a False discovery rate of 5% (corresponding to p < 0.0017) were replicated in patients with T2DM in an independent cohort. We also investigated if proteins mediated the longitudinal association between plasma leptin and the incidence of major cardiovascular events (MACE). One protein, adipocyte fatty acid binding protein (A-FABP), was significantly associated with leptin in both the discovery phase [95% CI (0.06, 0.17) p = 0.00002] and the replication cohort [95% CI (0.12, 0.39) p = 0.0003]. Multiplicative interaction analyses in the two cohorts suggest a stronger association between A-FABP and leptin in men than in women. In longitudinal analyses, the association between leptin and MACE was slightly attenuated after adding A-FABP to the multivariate model. Our analysis identified a consistent association between leptin and A-FABP in two independent cohorts of patients with T2DM, particularly in men.Trial registration: ClinicalTrials.gov identifier NCT01049737.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Health and Welfare
- Hälsa och välfärd
Publication and Content Type
- ref (subject category)
- art (subject category)
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