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Probabilistic infer...
Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits
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Patxot, Marion (author)
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Banos, Daniel Trejo (author)
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Kousathanas, Athanasios (author)
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Orliac, Etienne J. (author)
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Ojavee, Sven E. (author)
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Moser, Gerhard (author)
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Holloway, Alexander (author)
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Sidorenko, Julia (author)
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Kutalik, Zoltan (author)
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Magi, Reedik (author)
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Visscher, Peter M. (author)
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- Rönnegård, Lars (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Högskolan Dalarna,Statistik,Swedish University of Agricultural Science,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Dalarna University
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Robinson, Matthew R. (author)
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(creator_code:org_t)
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- 2021-11-30
- 2021
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Abstract
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- We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 seconds per iteration to estimate 8.4 million SNP-effects and 78 SNP-heritability parameters in the UK Biobank. We find that only ≤10% of the genetic variation captured for height, body mass index, cardiovascular disease, and type 2 diabetes is attributable to proximal regulatory regions within 10kb upstream of genes, while 12-25% is attributed to coding regions, 32–44% to introns, and 22-28% to distal 10-500kb upstream regions. Up to 24% of all cis and coding regions of each chromosome are associated with each trait, with over 3,100 independent exonic and intronic regions and over 5,400 independent regulatory regions having ≥95% probability of contributing ≥0.001% to the genetic variance of these four traits. Our open-source software (GMRM) provides a scalable alternative to current approaches for biobank data.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Patxot, Marion
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Banos, Daniel Tr ...
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Kousathanas, Ath ...
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Orliac, Etienne ...
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Ojavee, Sven E.
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Moser, Gerhard
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show more...
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Holloway, Alexan ...
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Sidorenko, Julia
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Kutalik, Zoltan
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Magi, Reedik
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Visscher, Peter ...
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Rönnegård, Lars
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Robinson, Matthe ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature Communica ...
- By the university
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Högskolan Dalarna
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Swedish University of Agricultural Sciences