Rhabdomyolysis/myoglobinemia and NSAID during 48-hours ultra-endurance exercise (adventure racing)

• Purpose: To determine if rhabdomyolysis with myoglobinemia exists during a 48+ hour adventure race and if there is a correlation with NSAID use, race time and perceived pain or exertion. Method: Blood samples for analyses of myoglobin (Mb) were collected, and perception of exertion and pain registered on the Borg-RPE and CR scales, from 20 subjects (3 female, 17 male) Pre, Mid and Post race. Subjects were asked about NSAID use at each sampling and within 12 hours pre race. Result: A significant rise in Mb was observed throughout the race, with the NSAID group (n=6) having significantly lower Mb-Post than the no-NSAID group (n=14). High Mb-Pre and Post correlated to shorter race time and high Mb-Pre to lower Pain-Post. Race time also correlated to NSAID use, with the NSAID group having significantly longer race time than the no-NSAID group. Conclusion: Rhabdomyolysis with myoglobinemia, which might be reduced with NSAID use, exists during a 48+ hour adventure race. Indications that high Mb-levels correlate with shorter race time and less pain, and the reasons for the NSAID groups longer race time, need further investigation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)

SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)

SOCIAL SCIENCES  -- Psychology (hsv//eng)

Keyword

Prolonged exercise

multisport

myoglobin

myoglobinemia

analgesics

exertional rhabdomyolysis

Internal medicine

Invärtesmedicin

Physiology

Fysiologi

Sports

Idrott

Medicin/Teknik

Medicine/Technology

Publication and Content Type

ref (subject category)

art (subject category)