Dietary inorganic nitrate improves mitochondrial efficiency in humans.

Larsen, Filip, 1977- (author): Karolinska Institutet,Gymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp

Sahlin, Kent (author): Gymnastik- och idrottshögskolan,Forskningsgruppen Mitokondriell funktion och metabol kontroll

Ekblom, Björn (author): Gymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp

(creator_code:org_t)

Elsevier BV, 2011
2011
English.
In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 13:2, s. 149-159

Related links:: http://www.cell.com/...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

Nitrate, an inorganic anion abundant in vegetables, is converted in vivo to bioactive nitrogen oxides including NO. We recently demonstrated that dietary nitrate reduces oxygen cost during physical exercise, but the mechanism remains unknown. In a double-blind crossover trial we studied the effects of a dietary intervention with inorganic nitrate on basal mitochondrial function and whole-body oxygen consumption in healthy volunteers. Skeletal muscle mitochondria harvested after nitrate supplementation displayed an improvement in oxidative phosphorylation efficiency (P/O ratio) and a decrease in state 4 respiration with and without atractyloside and respiration without adenylates. The improved mitochondrial P/O ratio correlated to the reduction in oxygen cost during exercise. Mechanistically, nitrate reduced the expression of ATP/ADP translocase, a protein involved in proton conductance. We conclude that dietary nitrate has profound effects on basal mitochondrial function. These findings may have implications for exercise physiology- and lifestyle-related disorders that involve dysfunctional mitochondria.

By the author/editor: Larsen, Filip, 1 ...; Schiffer, TA; Borniquel, S; Sahlin, Kent; Ekblom, Björn; Lundberg, JO; show more...; Weitzberg, E; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

By the university: The Swedish School of Sport and Health Sciences; Karolinska Institutet

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