Cardiorespiratory fitness predicts insulin action and secretion in healthy individuals.

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Larsen, Filip JKarolinska Institutet,Gymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp (author)

Cardiorespiratory fitness predicts insulin action and secretion in healthy individuals.

Article/chapterEnglish2012

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Elsevier BV,2012
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LIBRIS-ID:oai:DiVA.org:gih-2587
https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-2587URI
https://doi.org/10.1016/j.metabol.2011.05.010DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:123775513URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Long-term cardiorespiratory fitness (CRF) and the development of type 2 diabetes mellitus are inversely correlated. Here, we examined the relationships between peak oxygen uptake (VO(2)peak), on the one hand, and glucose infusion rate at rest (GIR(rest)) and during exercise (GIR(exercise)), as well as insulin secretion (both the early and late phases of response [area under the curve {AUC}(insulin)]), on the other. Eight male and 4 female healthy, lean, nonsmoking volunteers were recruited. The VO(2)peak was measured during graded exercise on a cycle ergometer until exhaustion was reached. The GIR(rest) and GIR(exercise) were determined using a euglycemic-hyperinsulinemic clamp, and insulin secretion at rest was evaluated with an intravenous glucose tolerance test. The VO(2)peak correlated positively to GIR(rest) (r = 0.81, P = .001) and GIR(exercise) (r = 0.87, P < .001) and negatively to AUC(insulin) (r = -0.64, P = .03). The respiratory exchange ratio (RER) during insulin infusion was positively correlated to GIR(rest) (r = 0.83, P < .001) and GIR(exercise) (r = 0.86, P < .01) and negatively correlated to both the early insulin response (r = -0.86, P < .0001) and AUC(insulin) (r = -0.87, P = .001). The VO(2)peak accounted for 45% of the variability in RER (R(2) = 0.45, P = .035). In this healthy population, CRF and RER were highly correlated to insulin sensitivity and secretion, as well as to the ability to alter the substrate being oxidized during exercise. These findings highlight the importance of good CRF to maintaining normal insulin action.

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Medicin/Teknik
Medicine/Technology

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Anderson, MartinKarolinska Institutet (author)
Ekblom, BjörnGymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp(Swepub:gih)bjorne (author)
Nyström, ThomasKarolinska Institutet (author)
Gymnastik- och idrottshögskolanBjörn Ekbloms forskningsgrupp (creator_code:org_t)

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In:Metabolism: Elsevier BV61:1, s. 12-60026-04951532-8600

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By the author/editor: Larsen, Filip J; Anderson, Martin; Ekblom, Björn; Nyström, Thomas

Articles in the publication: Metabolism

By the university: The Swedish School of Sport and Health Sciences; Karolinska Institutet

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