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Personalized Preven...
Personalized Preventive Medicine : Genetics and the Response to Regular Exercise in Preventive Interventions
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Bouchard, Claude (author)
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- Antunes-Correa, Ligia M. (author)
- Karolinska Institutet
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Ashley, Euan A. (author)
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Franklin, Nina (author)
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Hwang, Paul M. (author)
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- Mattsson, C. Mikael (author)
- Gymnastik- och idrottshögskolan,Åstrandlaboratoriet
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Negrao, Carlos E. (author)
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Phillips, Shane A. (author)
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Sarzynski, Mark A. (author)
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Wang, Ping-yuan (author)
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Wheeler, Matthew T. (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Progress in cardiovascular diseases. - : Elsevier BV. - 0033-0620 .- 1873-1740. ; 57:4, s. 337-346
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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Abstract
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- Regular exercise and a physically active lifestyle have favorable effects on health. Several issues related to this theme are addressed in this report. A comment on the requirements of personalized exercise medicine and in-depth biological profiling along with the opportunities that they offer is presented. This is followed by a brief overview of the evidence for the contributions of genetic differences to the ability to benefit from regular exercise. Subsequently, studies showing that mutations in TP53 influence exercise capacity in mice and humans are succinctly described. The evidence for effects of exercise on endothelial function in health and disease also is covered. Finally, changes in cardiac and skeletal muscle in response to exercise and their implications for patients with cardiac disease are summarized. Innovative research strategies are needed to define the molecular mechanisms involved in adaptation to exercise and to translate them into useful clinical and public health applications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Personalized medicine
- Individual differences
- Genetics
- Mitochondria
- Endothelium
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bouchard, Claude
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Antunes-Correa, ...
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Ashley, Euan A.
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Franklin, Nina
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Hwang, Paul M.
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Mattsson, C. Mik ...
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show more...
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Negrao, Carlos E ...
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Phillips, Shane ...
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Sarzynski, Mark ...
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Wang, Ping-yuan
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Wheeler, Matthew ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Progress in card ...
- By the university
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The Swedish School of Sport and Health Sciences
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Karolinska Institutet