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- Mattsson, C. MikaelKarolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för idrotts- och hälsovetenskap,Forskningsgruppen för fysisk aktivitet, prestation och hälsa (author)
Sports genetics moving forward - lessons learned from medical research
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- American Physiological Society,2016
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:gih-4286
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-4286URI
- https://doi.org/10.1152/physiolgenomics.00109.2015DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:133103381URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Sports genetics can take advantage of lessons learned from human disease genetics. By righting past mistakes and increasing scientific rigor, the breadth and depth of knowledge in the field can be magnified. We present an outline of challenges facing sports genetics in the light of experiences from medical research.Sports performance is complex, resulting from a combination of a wide variety of different traits and attributes. Improving sports genetics will foremost require analyses based on detailed phenotyping. In order to find widely valid, reproducible common variants associated with athletic phenotypes, study sample sizes must be dramatically increased. One paradox is that in order to confirm relevance, replications in specific populations must be undertaken. Family studies of athletes may facilitate the discovery of rare variants with large effects on athletic phenotypes. The complexity of the human genome, combined with the complexity of athletic phenotypes, will require additional metadata and biological validation to identify a comprehensive set of genes involved.Analysis of personal genetic and multiomic profiles contribute to our conceptualization of precision medicine; the same will be the case in precision sports science. In the refinement of sports genetics it is essential to evaluate similarities and differences between genders and among ethnicities. Sports genetics to date have been hampered by small sample sizes and biased methodology which can lead to erroneous associations and overestimation of effect sizes. Consequently, currently available genetic tests based on these inherently limited data cannot predict athletic performance with any accuracy.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Idrottsvetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Sport and Fitness Sciences hsv//eng
- Sports genetics
- individual differences
- genetic testing
- sports medicine
- precision medicine
- Medicin/Teknik
- Medicine/Technology
Added entries (persons, corporate bodies, meetings, titles ...)
- Wheeler, MatthewStanford University,Ashley Lab (author)
- Waggott, DarylStanford University,Ashley Lab (author)
- Caleshu, ColleenStanford University,Ashley Lab (author)
- Ashley, Euan A.Stanford University,Ashley Lab (author)
- Gymnastik- och idrottshögskolanInstitutionen för idrotts- och hälsovetenskap (creator_code:org_t)
Related titles
- In:Physiological Genomics: American Physiological Society48:3, s. 175-1821094-83411531-2267
Internet link
- https://doi.org/10.1152/physiolgenomics.00109.2015Fulltext
- https://www.physiology.org/doi/pdf/10.1152/physiolgenomics.00109.2015
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-4286
- https://doi.org/10.1152/physiolgenomics.00109.2015
- http://kipublications.ki.se/Default.aspx?queryparsed=id:133103381
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