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Superior Intrinsic ...
Superior Intrinsic Mitochondrial Respiration in Women Than in Men.
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- Cardinale, Daniele A., 1982- (author)
- Gymnastik- och idrottshögskolan,Forskningsgruppen Mitokondriell funktion och metabol kontroll,Swedish Sch Sport & Hlth Sci, Stockholm
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- Larsen, Filip J, 1977- (author)
- Gymnastik- och idrottshögskolan,Forskningsgruppen Mitokondriell funktion och metabol kontroll,Swedish Sch Sport & Hlth Sci, Stockholm
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- Schiffer, Tomas A (author)
- Karolinska Institute,Karolinska Inst, Stockholm
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- Morales-Alamo, David (author)
- University of Las Palmas de Gran Canaria,Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain; Res Inst Biomed & Hlth Sci IUIBS, Las Palmas De Gran Canad, Gran Canaria, Spain
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- Ekblom, Björn, 1938- (author)
- Gymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp,Swedish Sch Sport & Hlth Sci, Stockholm
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- Calbet, Jose A L (author)
- University of Las Palmas de Gran Canaria,Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain; Res Inst Biomed & Hlth Sci IUIBS, Las Palmas De Gran Canad, Gran Canaria, Spain; Univ British Columbia, Vancouver, BC, Canada
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- Holmberg, Hans-Christer, 1958- (author)
- Mittuniversitetet,Avdelningen för hälsovetenskap,Univ British Columbia, Vancouver, BC, Canada,Mittuniversitetet, Avdelningen för hälsovetenskap,Mid Sweden University, Östersund, The University of British Columbia, Vancouver, BC, Canada.
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- Boushel, Robert (author)
- The University of British Columbia, Vancouver, BC, Canada.,Univ British Columbia, Vancouver, BC, Canada
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(creator_code:org_t)
- 2018-08-17
- 2018
- English.
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In: Frontiers in Physiology. - : Frontiers Media SA. - 1664-042X. ; 9
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Abstract
Subject headings
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- Sexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondrial function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial oxygen affinity (p50mito) in relation to biological sex in human. A skeletal muscle biopsy was donated by nine active women, and ten men matched for maximal oxygen consumption (VO2max) and by nine endurance trained men. Intrinsic mitochondrial respiration, assessed in isolated mitochondria, was higher in women compared to men when activating complex I (CIP) and complex I+II (CI+IIP) (p < 0.05), and was similar to trained men (CIP, p = 0.053; CI+IIP, p = 0.066). Proton leak and p50mito were higher in women compared to men independent of VO2max. In conclusion, significant novel differences in mitochondrial oxidative function, intrinsic mitochondrial respiration and p50mito exist between women and men. These findings may represent an adaptation in the oxygen cascade in women to optimize muscle oxygen uptake to compensate for a lower oxygen delivery during exercise.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- OXPHOS
- endurance performance
- mitochondria
- mitochondrial function
- sexual dimorphism
- skeletal muscle
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cardinale, Danie ...
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Larsen, Filip J, ...
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Schiffer, Tomas ...
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Morales-Alamo, D ...
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Ekblom, Björn, 1 ...
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Calbet, Jose A L
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Holmberg, Hans-C ...
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Boushel, Robert
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Sport and Fitnes ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
- Articles in the publication
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Frontiers in Phy ...
- By the university
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The Swedish School of Sport and Health Sciences
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Mid Sweden University
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Luleå University of Technology
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Karolinska Institutet