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Transcranial contra...
Transcranial contrast-enhanced ultrasound in the rat brain reveals substantial hyperperfusion acutely post-stroke.
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- Premilovac, Dino (author)
- University of Tasmania, Hobart, Tasmania, Australia
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- Blackwood, Sarah J (author)
- Gymnastik- och idrottshögskolan,Åstrandlaboratoriet
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- Ramsay, Ciaran J (author)
- University of Tasmania, Hobart, Tasmania, Australia
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- Keske, Michelle A (author)
- Deakin University, Geelong, Victoria, Australia
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- Howells, David W (author)
- University of Tasmania, Hobart, Tasmania, Australia
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- Sutherland, Brad A (author)
- University of Tasmania, Hobart, Tasmania, Australia
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(creator_code:org_t)
- Sage Publications, 2020
- 2020
- English.
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In: Journal of Cerebral Blood Flow and Metabolism. - : Sage Publications. - 0271-678X .- 1559-7016. ; 40:5, s. 939-953
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Direct and real-time assessment of cerebral hemodynamics is key to improving our understanding of cerebral blood flow regulation in health and disease states such as stroke. While a number of sophisticated imaging platforms enable assessment of cerebral perfusion, most are limited either spatially or temporally. Here, we applied transcranial contrast-enhanced ultrasound (CEU) to measure cerebral perfusion in real-time through the intact rat skull before, during and after ischemic stroke, induced by intraluminal filament middle cerebral artery occlusion (MCAO). We demonstrate expected decreases in cortical and striatal blood volume, flow velocity and perfusion during MCAO. After filament retraction, blood volume and perfusion increased two-fold above baseline, indicative of acute hyperperfusion. Adjacent brain regions to the ischemic area and the contralateral hemisphere had increased blood volume during MCAO. We assessed our data using wavelet analysis to demonstrate striking vasomotion changes in the ischemic and contralateral cortices during MCAO and reperfusion. In conclusion, we demonstrate the application of CEU for real-time assessment of cerebral hemodynamics and show that the ischemic regions exhibit striking hyperemia post-MCAO. Whether this post-stoke hyperperfusion is sustained long-term and contributes to stroke severity is not known.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Ischemic stroke
- cerebral blood flow
- contrast-enhanced ultrasound
- middle cerebral artery occlusion
- rat
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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