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Mitochondrial oxyge...
Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake.
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- Larsen, Filip J, 1977- (author)
- Gymnastik- och idrottshögskolan,Forskningsgruppen Mitokondriell funktion och metabol kontroll,The Swedish School of Sport and Health Sciences, Stockholm, Sweden
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- Schiffer, T A (author)
- Karolinska Institutet
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- Zinner, C (author)
- University of Applied Sciences for Police and Administration of Hesse, Wiesbaden, Germany
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- Willis, S J (author)
- University of Lausanne, Lausanne, Switzerland
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- Morales-Alamo, D (author)
- University of Las Palmas de Gran Canaria, Gran Canaria, Spain
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- Calbet, Jal (author)
- University of Las Palmas de Gran Canaria, Gran Canaria, Spain
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- Boushel, R (author)
- The University of British Columbia, Vancouver, BC, Canada.
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- Holmberg, Hans-Christer, 1958- (author)
- Mittuniversitetet,Institutionen för hälsovetenskap,Swedish Winter Sports Research Centre,Mittuniversitetet, Institutionen för hälsovetenskap,Mid Sweden University, Östersund, Sweden.
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- Calbet, Jose A. L. (author)
- University of Las Palmas de Gran Canaria, Gran Canaria, Spain; The University of British Columbia, Vancouver, BC, Canada; The Norwegian School of Sport Sciences, Oslo, Norway
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(creator_code:org_t)
- 2020-03-19
- 2020
- English.
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In: Acta Physiologica. - : John Wiley & Sons. - 1748-1708 .- 1748-1716. ; 229:3
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Abstract
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- AIMS: The body responds to exercise training by profound adaptations throughout the cardiorespiratory and muscular systems, which may result in improvements in maximal oxygen consumption (VO2 peak) and mitochondrial capacity. By convenience, mitochondrial respiration is often measured at supra-physiological oxygen levels, an approach that ignores any potential regulatory role of mitochondrial affinity for oxygen (p50mito ) at physiological oxygen levels.METHODS: In this study, we examined the p50mito of mitochondria isolated from the Vastus lateralis and Triceps brachii in 12 healthy volunteers before and after a training intervention with 7 sessions of sprint interval training using both leg cycling and arm cranking. The changes in p50mito were compared to changes in whole-body VO2 peak.RESULTS: We here show that p50mito is similar in isolated mitochondria from the Vastus (40 ± 3.8 Pa) compared to Triceps (39 ± 3.3) but decreases (mitochondrial oxygen affinity increases) after 7 sessions of sprint interval training (to 26 ± 2.2 Pa in Vastus and 22 ± 2.7 Pa in Triceps, both p<0.01). The change in VO2 peak modeled from changes in p50mito was correlated to actual measured changes in VO2 peak (R2 =0.41, p=0.002).CONCLUSION: Together with mitochondrial respiratory capacity, p50mito is a critical factor when measuring mitochondrial function, it can decrease with sprint interval training and should be considered in the integrative analysis of the oxygen cascade from lung to mitochondria.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Keyword
- Mitochondria
- exercise
- high intensity training
- maximal oxygen consumption
- oxygen affinity
- sprint training
- training
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Larsen, Filip J, ...
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Schiffer, T A
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Zinner, C
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Willis, S J
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Morales-Alamo, D
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Calbet, Jal
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show more...
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Boushel, R
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Holmberg, Hans-C ...
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Calbet, Jose A. ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Sport and Fitnes ...
- Articles in the publication
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Acta Physiologic ...
- By the university
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The Swedish School of Sport and Health Sciences
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Mid Sweden University
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Luleå University of Technology
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Karolinska Institutet