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  • Ekblom Bak, Elin,1981-Gymnastik- och idrottshögskolan,Åstrandlaboratoriet (author)

Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds.

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-04-21
  • Sage Publications,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:gih-6161
  • https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-6161URI
  • https://doi.org/10.1177/2047487320916596DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170543URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143472552URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • AimsThe purpose of this study was to analyse the association of leisure-time physical activity of different intensities at baseline, and cardiovascular disease incidence, cardiovascular disease mortality and all-cause mortality in a population-based sample of 60-year-old men and women with and without established metabolic syndrome, for more than 20 years of follow-up. A secondary aim was to study which cardiometabolic factors may mediate the association between physical activity and long-term outcomes.MethodsA total of 3693 participants (53% women) underwent physical examination and laboratory tests, completed an extensive questionnaire at baseline 1997–1999 and were followed until their death or until 31 December 2017. First-time cardiovascular disease events and death from any cause were ascertained through regular examinations of national registers.ResultsMetabolic syndrome prevalence was 23.0%. In metabolic syndrome participants, light physical activity attenuated cardiovascular disease incidence (hazard ratio = 0.71; 95% confidence interval 0.50–1.00) compared to sedentary (reference) after multi-adjustment. Moderate/high physical activity was inversely associated with both cardiovascular disease and all-cause mortality, but became non-significant after multi-adjustment. Sedentary non-metabolic syndrome participants had lower cardiovascular disease incidence (0.47; 0.31–0.72) but not significantly different cardiovascular disease (0.61; 0.31–1.19) and all-cause mortality (0.92; 0.64–1.34) compared to sedentary metabolic syndrome participants. Both light and moderate/high physical activity were inversely associated with cardiovascular disease and all-cause mortality in non-metabolic syndrome participants (p<0.05). There were significant variations in several central cardiometabolic risk factors with physical activity level in non-metabolic syndrome participants. Fibrinogen mediated the protective effects of physical activity in non-metabolic syndrome participants.ConclusionPhysical activity of different intensities attenuated cardiovascular risk and mortality in 60-year old men and women with metabolic syndrome during a 20-year follow-up.

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  • Halldin, MatsSophiahemmet Hospital, Sweden. (author)
  • Vikström, MaxKarolinska Institutet, Sweden. (author)
  • Stenling, Andreas,1982-Umeå universitet,Institutionen för psykologi,Umeå University, Sweden(Swepub:umu)anslil01 (author)
  • Gigante, BrunaKarolinska Institutet (author)
  • de Faire, UlfKarolinska Institutet (author)
  • Leander, KarinKarolinska Institutet (author)
  • Hellénius, Mai-LisKarolinska Institutet (author)
  • Gymnastik- och idrottshögskolanÅstrandlaboratoriet (creator_code:org_t)

Related titles

  • In:European Journal of Preventive Cardiology: Sage Publications8:12, s. 1376-13852047-48732047-4881

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