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The effect of break...
The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity.
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- Bojsen-Møller, Emil (author)
- Gymnastik- och idrottshögskolan,Åstrandlaboratoriet,Fysisk aktivitet och hjärnhälsa
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- Ekblom, Maria, 1974- (author)
- Karolinska Institutet,Gymnastik- och idrottshögskolan,Laboratoriet för biomekanik och motorisk kontroll (BMC)
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- Tarassova, Olga (author)
- Gymnastik- och idrottshögskolan,Laboratoriet för biomekanik och motorisk kontroll (BMC)
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- Dunstan, D W (author)
- Baker Heart and Diabetes Institute, Melbourne, VIC, Australia
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- Ekblom, Örjan, 1971- (author)
- Gymnastik- och idrottshögskolan,Åstrandlaboratoriet
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(creator_code:org_t)
- 2020-08-28
- 2020
- English.
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In: Experimental Brain Research. - : Springer. - 0014-4819 .- 1432-1106. ; 238, s. 2497-2506
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Abstract
Subject headings
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- Paired associative stimulation (PAS) can induce plasticity in the motor cortex, as measured by changes in corticospinal excitability (CSE). This effect is attenuated in older and less active individuals. Although a single bout of exercise enhances PAS-induced plasticity in young, physically inactive adults, it is not yet known if physical activity interventions affect PAS-induced neuroplasticity in middle-aged inactive individuals. Sixteen inactive middle-aged office workers participated in a randomized cross-over design investigating how CSE and short-interval intracortical inhibition (SICI) were affected by PAS preceded by 3 h of sitting (SIT), 3 h of sitting interrupted every 30 min by 3 min of frequent short bouts of physical activity (FPA) and 2.5 h of sitting followed by 25 min of moderate-intensity exercise (EXE). Transcranial magnetic stimulation was applied over the primary motor cortex (M1) of the dominant abductor pollicis brevis to induce recruitment curves before and 5 min and 30 min post-PAS. Linear mixed models were used to compare changes in CSE using time and condition as fixed effects and subjects as random effects. There was a main effect of time on CSE and planned within-condition comparisons showed that CSE was significantly increased from baseline to 5 min and 30 min post-PAS, in the FPA condition, with no significant changes in the SIT or EXE conditions. SICI decreased from baseline to 5 min post-PAS, but this was not related to changes in CSE. Our findings suggest that in middle-aged inactive adults, FPAs may promote corticospinal neuroplasticity. Possible mechanisms are discussed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Corticospinal excitability
- Paired associative stimulation
- Sedentary behaviour
- Transcranial magnetic stimulation
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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