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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 14313naa a2200973 4500 | |
| 001 | oai:DiVA.org:gih-6892 | |
| 003 | SwePub | |
| 008 | 220104s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-68922 URI |
| 024 | 7 | a https://doi.org/10.1161/circulationaha.121.0553402 DOI |
| 040 | a (SwePub)gih | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bergström, Göranu Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Departments of Clinical Physiology (G. Bergström, O.H.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 245 | 1 0 | a Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population |
| 264 | 1 | b Wolters Kluwer,c 2021 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a coronary angiography | |
| 653 | a coronary artery disease | |
| 653 | a epidemiology | |
| 653 | a plaque | |
| 653 | a atherosclerotic | |
| 653 | a primary prevention | |
| 653 | a tomography. | |
| 653 | a Medicin/Teknik | |
| 653 | a Medicine/Technology | |
| 700 | 1 | a Persson, Margarethau Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.;Departments of Internal Medicine (M.P.), Skåne University Hospital, Malmö, Sweden.4 aut |
| 700 | 1 | a Adiels, Martinu Sahlgrenska Academy, and School of Public Health and Community Medicine, Institute of Medicine (M.A., C.B.), University of Gothenburg, Sweden.4 aut |
| 700 | 1 | a Björnson, Eliasu Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.4 aut |
| 700 | 1 | a Bonander, Carlu Sahlgrenska Academy, and School of Public Health and Community Medicine, Institute of Medicine (M.A., C.B.), University of Gothenburg, Sweden.4 aut |
| 700 | 1 | a Ahlström, Håkanu Section of Radiology, Department of Surgical Sciences (H.A., O.D.), Uppsala University, Sweden.4 aut |
| 700 | 1 | a Alfredsson, Joakimu Departments of Cardiology (J.A., E.S.), Linköping University, Sweden.;Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.4 aut |
| 700 | 1 | a Angerås, Oskaru Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Cardiology (O.A.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 700 | 1 | a Berglund, Göranu Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.4 aut |
| 700 | 1 | a Blomberg, Andersu Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.4 aut |
| 700 | 1 | a Brandberg, Johnu Department of Radiology, Institute of Clinical Sciences (J.B., E.F., A.F.), University of Gothenburg, Sweden.;Radiology (J.B., E.F., A.F.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 700 | 1 | a Börjesson, Matsu Institute of Medicine (M.B.), University of Gothenburg, Sweden.;Center for Health and Performance (M.B.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 700 | 1 | a Cederlund, Kerstinu Department of Clinical Science, Intervention and Technology (K.C.), Karolinska Institutet, Stockholm, Sweden.4 aut |
| 700 | 1 | a de Faire, Ulfu Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine (U.d.F.), Karolinska Institutet, Stockholm, Sweden.4 aut |
| 700 | 1 | a Duvernoy, Olovu Section of Radiology, Department of Surgical Sciences (H.A., O.D.), Uppsala University, Sweden.4 aut |
| 700 | 1 | a Ekblom, Örjan,d 1971-u Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa4 aut0 (Swepub:gih)orjane |
| 700 | 1 | a Engström, Gunnaru Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.4 aut |
| 700 | 1 | a Engvall, Jan E.u Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.;Clinical Physiology (J.E.E.), Linköping University, Sweden.;CMIV, Centre of Medical Image Science and Visualization (J.E.E., A.P., C.J.Ö.), Linköping University, Sweden.4 aut |
| 700 | 1 | a Fagman, Erikau Department of Radiology, Institute of Clinical Sciences (J.B., E.F., A.F.), University of Gothenburg, Sweden.;Radiology (J.B., E.F., A.F.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 700 | 1 | a Eriksson, Matsu Department of Endocrinology, Metabolism & Diabetes and Clinical Research Center, Karolinska University Hospital Huddinge, Stockholm, Sweden (M.E.).4 aut |
| 700 | 1 | a Erlinge, Davidu Department of Clinical Sciences Lund, Cardiology, Lund University and Skåne University Hospital, Lund, Sweden (D.E., M.A.M.).4 aut |
| 700 | 1 | a Fagerberg, Björnu Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 700 | 1 | a Flinck, Agnetau Department of Radiology, Institute of Clinical Sciences (J.B., E.F., A.F.), University of Gothenburg, Sweden.;Radiology (J.B., E.F., A.F.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 700 | 1 | a Gonçalves, Isabelu Department of Clinical Sciences Malmö (I.G.), Lund University and Skåne University Hospital, Lund, Sweden.4 aut |
| 700 | 1 | a Hagström, Emilu Cardiology (E.H.), Uppsala University, Sweden.;Department of Medical Sciences, and Uppsala Clinical Research Center (E.H.), Uppsala University, Sweden.4 aut |
| 700 | 1 | a Hjelmgren, Olau Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Departments of Clinical Physiology (G. Bergström, O.H.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 700 | 1 | a Lind, Larsu Clinical Epidemiology (L.L., J.S.), Uppsala University, Sweden.4 aut |
| 700 | 1 | a Lindberg, Evau Respiratory, Allergy and Sleep Research (E.L.), Uppsala University, Sweden.4 aut |
| 700 | 1 | a Lindqvist, Peru Department of Surgical and Perioperative Sciences (P.L.), Umeå University, Sweden.4 aut |
| 700 | 1 | a Ljungberg, Johanu Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.4 aut |
| 700 | 1 | a Magnusson, Martinu Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.;Cardiology (M. Magnusson), Skåne University Hospital, Malmö, Sweden.;Wallenberg Center for Molecular Medicine, Lund University, Sweden (M. Magnusson).;North-West University, Hypertension in Africa Research Team (HART), Potchefstroom, South Africa (M. Magnusson).4 aut |
| 700 | 1 | a Mannila, Mariau Heart and Vascular Theme, Department of Cardiology, and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden (M. Mannila).4 aut |
| 700 | 1 | a Markstad, Hannau Experimental Cardiovascular Research, Clinical Research Center, Clinical Sciences Malmö (H.M.), Lund University, Malmö, Sweden.;Center for Medical Imaging and Physiology (H.M.), Lund University and Skåne University Hospital, Lund, Sweden.4 aut |
| 700 | 1 | a Mohammad, Moman A.u Department of Clinical Sciences Lund, Cardiology, Lund University and Skåne University Hospital, Lund, Sweden (D.E., M.A.M.).4 aut |
| 700 | 1 | a Nystrom, Fredrik H.u Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.4 aut |
| 700 | 1 | a Ostenfeld, Ellenu Department of Clinical Sciences Lund, Clinical Physiology (E.O.), Lund University and Skåne University Hospital, Lund, Sweden.4 aut |
| 700 | 1 | a Persson, Andersu Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.;Radiology (A.P.), Linköping University, Sweden.;CMIV, Centre of Medical Image Science and Visualization (J.E.E., A.P., C.J.Ö.), Linköping University, Sweden.4 aut |
| 700 | 1 | a Rosengren, Annikau Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 700 | 1 | a Sandström, Anetteu Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.4 aut |
| 700 | 1 | a Själander, Andersu Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.4 aut |
| 700 | 1 | a Sköld, Magnus C.u Respiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine (M.C.S.), Karolinska Institutet, Stockholm, Sweden.;Department of Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden (M.C.S.).4 aut |
| 700 | 1 | a Sundström, Johanu Clinical Epidemiology (L.L., J.S.), Uppsala University, Sweden.;The George Institute for Global Health, University of New South Wales, Sydney, Australia (J.S.).4 aut |
| 700 | 1 | a Swahn, Evau Departments of Cardiology (J.A., E.S.), Linköping University, Sweden.;Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.4 aut |
| 700 | 1 | a Söderberg, Stefanu Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.4 aut |
| 700 | 1 | a Torén, Kjellu Occupational and Environmental Medicine/School of Public Health and Community Medicine (K.T.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.4 aut |
| 700 | 1 | a Östgren, Carl Johanu Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.;CMIV, Centre of Medical Image Science and Visualization (J.E.E., A.P., C.J.Ö.), Linköping University, Sweden.4 aut |
| 700 | 1 | a Jernberg, Tomasu Department of Clinical Sciences, Danderyd University Hospital (T.J.), Karolinska Institutet, Stockholm, Sweden.4 aut |
| 710 | 2 | a Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Departments of Clinical Physiology (G. Bergström, O.H.), Region Västra Götaland, Gothenburg, Sweden.b Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.;Departments of Internal Medicine (M.P.), Skåne University Hospital, Malmö, Sweden.4 org |
| 773 | 0 | t Circulationd : Wolters Kluwerg 144:12, s. 916-929q 144:12<916-929x 0009-7322x 1524-4539 |
| 856 | 4 | u https://doi.org/10.1161/circulationaha.121.055340y Fulltext |
| 856 | 4 | u https://gih.diva-portal.org/smash/get/diva2:1624476/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.121.055340 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-6892 |
| 856 | 4 8 | u https://doi.org/10.1161/circulationaha.121.055340 |
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