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Glioblastoma Cell M...
Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
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- Jiang, Yiwen (author)
- Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden.
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- Marinescu, Voichita Dana (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Xie, Yuan (author)
- Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab
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- Jarvius, Malin (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin
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- Maturi, Naga Prathyusha (author)
- Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab
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- Haglund, Caroline (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin
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- Olofsson, Sara (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Lindberg, Nanna (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Olofsson, Tommie (author)
- Natl Board Forens Med, Dept Forens Med, Box 1024, S-75140 Uppsala, Sweden.
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- Leijonmarck, Caroline (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Hesselager, Göran (author)
- Uppsala universitet,Neurokirurgi
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- Alafuzoff, Irina (author)
- Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab
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- Fryknäs, Mårten (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin
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- Larsson, Rolf (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin
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- Nelander, Sven (author)
- Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab
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- Uhrbom, Lene (author)
- Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 18:4, s. 977-990
- Related links:
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https://doi.org/10.1...
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The identity of the glioblastoma (GBM) cell of origin and its contributions to disease progression and treatment response remain largely unknown. We have analyzed how the phenotypic state of the initially transformed cell affects mouse GBM development and essential GBM cell (GC) properties. We find that GBM induced in neural stem-cell-like glial fibrillary acidic protein (GFAP)-expressing cells in the subventricular zone of adult mice shows accelerated tumor development and produces more malignant GCs (mGC1GFAP) that are less resistant to cancer drugs, compared with those originating from more differentiated nestin- (mGC2NES) or 2,'3'-cyclic nucleotide 3'-phosphodiesterase (mGC3CNP)-expressing cells. Transcriptome analysis of mouse GCs identified a 196 mouse cell origin (MCO) gene signature that was used to partition 61 patient-derived GC lines. Human GC lines that clustered with the mGC1GFAP cells were also significantly more self-renewing, tumorigenic, and sensitive to cancer drugs compared with those that clustered with mouse GCs of more differentiated origin.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- cancer stem cell
- cell of origin
- central nervous system
- drug response
- glioblastoma
- glioma
- mouse model
- neural stem cell
- oligodendrocyte precursor cell
- self-renewal
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Jiang, Yiwen
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Marinescu, Voich ...
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Xie, Yuan
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Jarvius, Malin
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Maturi, Naga Pra ...
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Haglund, Carolin ...
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Olofsson, Sara
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Lindberg, Nanna
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Olofsson, Tommie
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Leijonmarck, Car ...
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Hesselager, Göra ...
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Alafuzoff, Irina
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Fryknäs, Mårten
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Larsson, Rolf
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Nelander, Sven
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Uhrbom, Lene
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Cell Reports
- By the university
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The Swedish School of Sport and Health Sciences
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Uppsala University
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Karolinska Institutet