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  • Baldanzi, GabrielUppsala University,Uppsala universitet,Molekylär epidemiologi,Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden (author)

Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS.

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Elsevier,2024
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:gih-8120
  • https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-8120URI
  • https://doi.org/10.1016/j.ebiom.2024.104989DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-47980URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-522177URI
  • https://gup.ub.gu.se/publication/334659URI
  • https://lup.lub.lu.se/record/59dd698e-633c-415e-ba2e-7ec8a9f2e15fURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:155254076URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Previous population-based studies investigating the relationship between physical activity and the gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated the associations of accelerometer-based sedentary (SED), moderate-intensity (MPA), and vigorous-intensity (VPA) physical activity with the gut microbiota using cross-sectional data from the Swedish CArdioPulmonary bioImage Study.METHODS: In 8416 participants aged 50-65, time in SED, MPA, and VPA were estimated with hip-worn accelerometer. Gut microbiota was profiled using shotgun metagenomics of faecal samples. We applied multivariable regression models, adjusting for sociodemographic, lifestyle, and technical covariates, and accounted for multiple testing.FINDINGS: Overall, associations between time in SED and microbiota species abundance were in opposite direction to those for MPA or VPA. For example, MPA was associated with lower, while SED with higher abundance of Escherichia coli. MPA and VPA were associated with higher abundance of the butyrate-producers Faecalibacterium prausnitzii and Roseburia spp. We observed discrepancies between specific VPA and MPA associations, such as a positive association between MPA and Prevotella copri, while no association was detected for VPA. Additionally, SED, MPA and VPA were associated with the functional potential of the microbiome. For instance, MPA was associated with higher capacity for acetate synthesis and SED with lower carbohydrate degradation capacity.INTERPRETATION: Our findings suggest that sedentary and physical activity are associated with a similar set of gut microbiota species but in opposite directions. Furthermore, the intensity of physical activity may have specific effects on certain gut microbiota species.FUNDING: European Research Council, Swedish Heart-Lung Foundation, Swedish Research Council, Knut and Alice Wallenberg Foundation.

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  • Sayols-Baixeras, SergiUppsala University,Uppsala universitet,Molekylär epidemiologi,Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; CIBER Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.(Swepub:uu)sersa467 (author)
  • Ekblom Bak, Elin,1981-Swedish School of Sport and Health Sciences,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa(Swepub:gih)eline (author)
  • Ekblom, Örjan,1971-Swedish School of Sport and Health Sciences,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa(Swepub:gih)orjane (author)
  • Dekkers, Koen F.Uppsala University,Uppsala universitet,Molekylär epidemiologi,Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)koede543 (author)
  • Hammar, UlfUppsala University,Uppsala universitet,Molekylär epidemiologi,Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)ulfha881 (author)
  • Nguyen, Diem,PhDUppsala University,Uppsala universitet,Molekylär epidemiologi,Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)dieng296 (author)
  • Ahmad, ShafqatUppsala University,Uppsala universitet,Molekylär epidemiologi,Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Preventive Medicine Division, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States(Swepub:lu)med-sta (author)
  • Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-upe (author)
  • Arvidsson, Daniel,1974University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kost- och idrottsvetenskap,Department of Food and Nutrition, and Sport Science,Center for Health and Performance, Department of Food and Nutrition, and Sport Science, University of Gothenburg, Gothenburg, Sweden.(Swepub:gu)xarvda (author)
  • Börjesson, Mats,1965University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Center for Lifestyle Intervention, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Medicine, Geriatric and Acute Medicine Östra, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xborjm (author)
  • Johansson, Peter J.,1975-Uppsala University,Uppsala universitet,Arbets- och miljömedicin,Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Occupational and Environmental Medicine, Uppsala University Hospital, Uppsala, Sweden.(Swepub:uu)petpa312 (author)
  • Smith, J. Gustav,1982Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine(Swepub:lu)med-gvs (author)
  • Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.(Swepub:gu)xbgort (author)
  • Lind, LarsUppsala University,Uppsala universitet,Klinisk epidemiologi,Clinical Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)larslind (author)
  • Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
  • Ärnlöv, Johan,1970-Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Division of Family Medicine and Primary Care, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Huddinge, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden.(Swepub:du)jan (author)
  • Kennedy, Beatrice,1982-Uppsala University,Uppsala universitet,Molekylär epidemiologi,Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)beake215 (author)
  • Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (author)
  • Fall, Tove,1979-Uppsala University,Uppsala universitet,Molekylär epidemiologi,Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:lu)med-tfa (author)
  • Uppsala universitetMolekylär epidemiologi (creator_code:org_t)

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  • In:EBioMedicine: Elsevier1002352-3964

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