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Elevated heart rate...
Elevated heart rate and decreased muscle endothelial nitric oxide synthase in early development of insulin resistance.
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- Blackwood, Sarah J (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik,Åstrand Laboratory
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- Tischer, Dominik (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- van de Ven, Myrthe P F (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Pontén, Marjan (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Edman, Sebastian (author)
- Karolinska Institutet, Sweden.
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- Horwath, Oscar, 1991- (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik,Åstrand Laboratory
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- Apro, William, 1980- (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik,Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden,Åstrand Laboratory
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- Röja, Julia (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Ekblom, Maria, 1974- (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,Department of Neuroscience, Karolinska Institutet, Sweden
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- Moberg, Marcus, 1986- (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Katz, Abram (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: American Journal of Physiology. Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Insulin resistance (IR) is a risk factor for the development of several major metabolic diseases. Muscle fiber composition is established early in life and is associated with insulin sensitivity. Hence, muscle fiber composition was used to identify early defects in the development of IR in healthy young individuals in the absence of clinical manifestations. Biopsies were obtained from the thigh muscle, followed by an intravenous glucose tolerance test. Indices of insulin action were calculated and cardiovascular measurements, analyses of blood and muscle were performed. Whole-body insulin sensitivity (SIgalvin) was positively related to expression of type I muscle fibers (r=0.49; P<0.001) and negatively related to resting heart rate (HR, r=-0.39; P<0.001), which was also negatively related to expression of type I muscle fibers (r=-0.41; P<0.001). Muscle protein expression of endothelial nitric oxide synthase (eNOS), whose activation results in vasodilation, was measured in two subsets of subjects expressing a high percentage of type I fibers (59±6%; HR = 57±9 beats/min; SIgalvin = 1.8±0.7 units) or low percentage of type I fibers (30±6%; HR = 71±11; SIgalvin = 0.8±0.3 units; P<0.001 for all variables vs. first group). eNOS expression was: 1. higher in subjects with high type I expression; 2. almost two-fold higher in pools of type I vs. II fibers; 3. only detected in capillaries surrounding muscle fibers; and 4. linearly associated with SIgalvin. These data demonstrate that an altered function of the autonomic nervous system and a compromised capacity for vasodilation in the microvasculature occur early in the development of IR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Keyword
- Heart rate
- Insulin resistance
- Muscle fiber composition
- Nitric oxide synthase
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Blackwood, Sarah ...
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Tischer, Dominik
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van de Ven, Myrt ...
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Pontén, Marjan
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Edman, Sebastian
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Horwath, Oscar, ...
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Apro, William, 1 ...
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Röja, Julia
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Ekblom, Maria, 1 ...
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Moberg, Marcus, ...
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Katz, Abram
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Sport and Fitnes ...
- Articles in the publication
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American Journal ...
- By the university
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The Swedish School of Sport and Health Sciences