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Oxygen therapy in s...
Oxygen therapy in suspected acute myocardial infarction and concurrent normoxemic chronic obstructive pulmonary disease : a prespecified subgroup analysis from the DETO2X-AMI trial.
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- Andell, Pontus (author)
- Karolinska Institutet
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- James, Stefan, 1964- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Clinical Research Center, Uppsala University
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- Östlund, Ollie (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Clinical Research Center, Uppsala University
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- Yndigegn, Troels (author)
- Department of Cardiology, Lund University
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- Sparv, David (author)
- Department of Cardiology, Lund University
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- Pernow, John (author)
- Karolinska Institutet
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- Jernberg, Tomas (author)
- Karolinska Institutet
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- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Department of Medical Sciences, Uppsala University
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- Herlitz, Johan, 1949- (author)
- Högskolan i Borås,Akademin för vård, arbetsliv och välfärd
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- Erlinge, David (author)
- Department of Cardiology, Lund University
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- Hofmann, Robin (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-12-01
- 2020
- English.
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In: European Heart Journal. - : Oxford University Press (OUP). - 2048-8726 .- 2048-8734. ; 9:8, s. 984-992
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) trial did not find any benefit of oxygen therapy compared to ambient air in normoxemic patients with suspected acute myocardial infarction. Patients with chronic obstructive pulmonary disease may both benefit and be harmed by supplemental oxygen. Thus we evaluated the effect of routine oxygen therapy compared to ambient air in normoxemic chronic obstructive pulmonary disease patients with suspected acute myocardial infarction.METHODS AND RESULTS: =0.77]); there were no significant treatment-by-chronic obstructive pulmonary disease interactions.CONCLUSIONS: Although chronic obstructive pulmonary disease patients had twice the mortality rate compared to non-chronic obstructive pulmonary disease patients, this prespecified subgroup analysis from the DETO2X-AMI trial on oxygen therapy versus ambient air in normoxemic chronic obstructive pulmonary disease patients with suspected acute myocardial infarction revealed no evidence for benefit of routine oxygen therapy consistent with the main trial's findings.CLINICAL TRIALS REGISTRATION: NCT02290080.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Acute myocardial infarction
- chronic obstructive pulmonary disease
- oxygen
- registry-based randomised clinical trial
- Människan i vården
- The Human Perspective in Care
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Andell, Pontus
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James, Stefan, 1 ...
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Östlund, Ollie
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Yndigegn, Troels
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Sparv, David
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Pernow, John
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show more...
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Jernberg, Tomas
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Lindahl, Bertil, ...
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Herlitz, Johan, ...
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Erlinge, David
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Hofmann, Robin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Heart J ...
- By the university
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University of Borås
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Uppsala University
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Karolinska Institutet