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- Herlitz, Johan[external] (author)
Effects of metoprolol CR/XL on mortality and hospitalizations in patients with heart failure and history of hypertension.
- Article/chapterEnglish2002
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- Churchill Livingstone,2002
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- LIBRIS-ID:oai:DiVA.org:hb-7970
- https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-7970URI
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- Language:English
- Summary in:English
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- BACKGROUND: We describe the effect of controlled-release/extended-release (CR/XL) metoprolol succinate once daily on mortality and hospitalizations among patients with a history of hypertension complicated by chronic systolic heart failure. METHODS AND RESULTS: We enrolled 3,991 patients with chronic heart failure of New York Heart Association functional class II-IV with an ejection fraction of < or = 0.40, stabilized with optimum standard therapy, in a double-blind randomized placebo-controlled study. A total of 1,747 patients (44%) had a history of hypertension; 871 were randomized to receive metoprolol CR/XL and 876 to receive placebo. Treatment with metoprolol CR/XL compared with placebo resulted in a significant reduction in total mortality (relative risk [RR], 0.61; 95% confidence interval [CI], 0.44-0.84; P =.0022), mainly because of reductions in sudden death (RR, 0.51; 95% CI, 0.33-0.79; P =.0022) and mortality from worsening heart failure (RR, 0.49; 95% CI, 0.25-0.99; P =.042). Total number of hospitalizations for worsening heart failure was reduced by 30% in the metoprolol CR/XL group compared with placebo (P =.015). Metoprolol CR/XL was well tolerated: 12% fewer patients withdrew from study medication (all-cause) compared with placebo (P =.048). CONCLUSIONS: A subgroup analysis of MERIT-HF shows that patients with heart failure and a history of hypertension received a similar benefit from metoprolol CR/XL treatment as all patients included in the total study.
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- Wikstrand, J (author)
- Denny, M (author)
- Fenster, P (author)
- Heywood, T (author)
- Masszi, G (author)
- Rasmussen, R (author)
- Thorgeirsson, G (author)
- Wachtell, K (author)
- [external] (creator_code:org_t)
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- In:Journal of Cardiac Failure: Churchill Livingstone8:1, s. 8-141071-91641532-8414
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