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Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

Nygren, Jens Martin, 1976- (author)
Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine,Lund University, Sweden
Liuba, Karina (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden
Breitbach, Martin (author)
Institute of Physiology I, Life & Brain Center, University of Bonn, Germany
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Stott, Simon (author)
Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden
Thorén, Lina (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden
Roell, Wilhelm (author)
Department of Cardiac Surgery, University of Bonn, Germany
Geisen, Caroline (author)
Institute of Physiology I, Life & Brain Center, University of Bonn, Germany
Sasse, Philipp (author)
Institute of Physiology I, Life & Brain Center, University of Bonn, Germany
Kirik, Deniz (author)
Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden
Björklund, Anders (author)
Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups,Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden
Nerlov, Claus (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden
Fleischmann, Bernd K (author)
Institute of Physiology I, Life & Brain Center, University of Bonn, Germany
Jovinge, Stefan (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,2Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden
Jacobsen, Sten Eirik W (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,2Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden
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 (creator_code:org_t)
2008-04-20
2008
English.
In: Nature Cell Biology. - London : Nature Publishing Group. - 1465-7392 .- 1476-4679. ; 10:5, s. 584-92
Related links:
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http://dx.doi.org/10...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

MEDICINE
MEDICIN

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ref (subject category)
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