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Differential expres...
Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects
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- Long, Yun Chau (author)
- Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
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- Kostovski, Emil (author)
- Sunnaas Hospital, Nesoddtangen, Norway
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- Boon, Hanneke, 1981- (author)
- Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
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- Hjeltnes, Nils (author)
- Sunnaas Hospital, Nesoddtangen, Norway
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- Krook, Anna (author)
- Karolinska Institutet,Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden & Department of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
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- Widegren, Ulrika (author)
- Karolinska Institutet,Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- Bethesda, MD : American Physiological Society, 2011
- 2011
- English.
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In: Journal of applied physiology. - Bethesda, MD : American Physiological Society. - 8750-7587 .- 1522-1601. ; 110:5, s. 1204-1210
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Skeletal muscle plays an important role in the regulation of energy homeostasis; therefore, the ability of skeletal muscle to adapt and alter metabolic gene expression in response to changes in physiological demands is critical for energy balance. Individuals with cervical spinal cord lesions are characterized by tetraplegia, impaired thermoregulation, and altered skeletal muscle morphology. We characterized skeletal muscle metabolic gene expression patterns, as well as protein content, in these individuals to assess the impact of spinal cord injury on critical determinants of skeletal muscle metabolism. Our results demonstrate that mRNA levels and protein expression of skeletal muscle genes essential for glucose storage are reduced, whereas expression of glycolytic genes is reciprocally increased in individuals with spinal cord injury. Furthermore, expression of genes essential for lipid oxidation is coordinately reduced in spinal cord injured subjects, consistent with a marked reduction of mitochondrial proteins. Thus spinal cord injury resulted in a profound and tightly coordinated change in skeletal muscle metabolic gene expression program that is associated with the aberrant metabolic features of the tissue. © 2011 the American Physiological Society.
Keyword
- glycogen storage
- metabolism
- oxidation
- physical inactivity
- tetraplegia
Publication and Content Type
- ref (subject category)
- art (subject category)
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