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Customisable 3D pri...
Customisable 3D printed microfluidics for integrated analysis and optimisation
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- Monaghan, T. (author)
- Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Ashby Road, Loughborough, United Kingdom
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- Harding, M. J. (author)
- Department of Chemistry, Loughborough University, Epinal Way, Loughborough, United Kingdom
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- Harris, R. A. (author)
- School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom
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- Friel, R. J., 1982- (author)
- Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Ashby Road, Loughborough, United Kingdom
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- Christie, S. D. R. (author)
- Department of Chemistry, Loughborough University, Epinal Way, Loughborough, United Kingdom
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(creator_code:org_t)
- Cambridge : Royal Society of Chemistry, 2016
- 2016
- English.
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In: Lab on a Chip. - Cambridge : Royal Society of Chemistry. - 1473-0197 .- 1473-0189. ; 16:17, s. 3362-3373
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels. © The Royal Society of Chemistry 2016.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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