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Current Progress in...
Current Progress in the Development of Zika Virus Vaccines
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- Zhou, Kehui (author)
- Zhejiang University City College, Hangzhou, China
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- Li, Chaoqun (author)
- Zhejiang University City College, Hangzhou, China
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- Shi, Wen (author)
- Zhejiang University City College, Hangzhou, China
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- Hu, Xiaodan (author)
- Zhejiang University City College, Hangzhou, China
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- Nandakumar, Kutty Selva, 1965- (author)
- Högskolan i Halmstad,Akademin för företagande, innovation och hållbarhet,Southern Medical University, Guangzhou, China
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- Jiang, Shibo (author)
- Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China
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- Zhang, Naru (author)
- Zhejiang University City College, Hangzhou, China
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(creator_code:org_t)
- 2021-09-09
- 2021
- English.
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In: Vaccines. - Basel : MDPI. - 2076-393X. ; 9:9
- Related links:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Zika virus (ZIKV) is an arbovirus first discovered in the Americas. ZIKV infection is insidious based on its mild clinical symptoms observed after infection. In Brazil, after 2015, ZIKV infection broke out on a large scale, and many infected pregnant women gave birth to babies with microcephaly. The teratogenic effects of the virus on the fetus and its effects on nerves and the immune system have attracted great attention. Currently, no specific prophylactics or therapeutics are clinically available to treat ZIKV infection. Development of a safe and effective vaccine is essential to prevent the rise of any potential pandemic. In this review, we summarize the latest research on Zika vaccine development based on different strategies, including DNA vaccines, subunit vaccines, live-attenuated vaccines, virus-vector-based vaccines, inactivated vaccines, virus-like particles (VLPs), mRNA-based vaccines, and others. We anticipate that this review will facilitate further progress toward the development of effective and safe vaccines against ZIKV infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Zika virus
- different strategies
- vaccine
Publication and Content Type
- ref (subject category)
- art (subject category)
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