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Inhibition of dengu...
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Yao, XingangSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
(author)
Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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Amsterdam :Elsevier,2018
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LIBRIS-ID:oai:DiVA.org:hh-48393
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https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-48393URI
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https://doi.org/10.1016/j.ejphar.2017.12.029DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding text: This work was supported by the Natural Science Foundation of China [81603118], Medical Scientific Research Foundation of Guangdong Province [A2016119], Research assistant project of Southern Medical University [C1032242], Open Project of Guangdong Provincial Key Laboratory of New Drug Screening, Educational Department of Jiangxi Province of China [GJJ151075], Natural Science Foundation of Jiangxi Province of China [20161BAB215194] and the Scientific Research Project of Jiujiang University [2015LGYB35].
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Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. However, antiviral drugs against this infection are not available. To identify novel anti-DENV compound from traditional Chinese medicine, we discovered the ethanol extract of Acorus tatarinowii Schott containing potent anti-DENV activity and diasarone-I was isolated from this extract. Diasarone-I has antiviral effect with half maximal effective concentration (EC50) of 4.5μM and half maximal cytotoxicity concentration (CC50) of >80μM. Time of drug addition assay suggested that this compound inhibited at RNA replication step in the DENV life cycle. Further, in silico analysis indicated that diasarone-I might act as an inhibitor of 2'O Methyltransferase of NS5. Diasarone-I has also decreased the DENV2-induced STAT1 phosphorylation and ISGs. In summary, we suggest that diasarone-I may be a 2'O Methyltransferase inhibitor and might serve as a potential candidate for the treatment of DENV2 infections. © 2017 Elsevier B.V.
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Ling, YunDepartment of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China
(author)
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Guo, SongxinSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
(author)
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He, ShijunSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
(author)
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Wang, JinanShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China
(author)
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Zhang, QingDepartment of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China
(author)
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Wu, WenyuZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, PR China
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Zou, MinSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
(author)
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Zhang, TingtingSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
(author)
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Nandakumar, Kutty Selva,1965-School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China(Swepub:hh)kutnam
(author)
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Chen, XiaoguangSchool of Public Health, Southern Medical University, Southern Medical University, Guangzhou, PR China
(author)
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Liu, ShuwenSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
(author)
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School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR ChinaDepartment of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China
(creator_code:org_t)
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In:European Journal of PharmacologyAmsterdam : Elsevier821, s. 11-200014-29991879-0712
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Guo, Songxin
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Wu, Wenyu
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