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  • Yao, XingangSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China (author)

Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • Amsterdam :Elsevier,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:hh-48393
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-48393URI
  • https://doi.org/10.1016/j.ejphar.2017.12.029DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding text: This work was supported by the Natural Science Foundation of China [81603118], Medical Scientific Research Foundation of Guangdong Province [A2016119], Research assistant project of Southern Medical University [C1032242], Open Project of Guangdong Provincial Key Laboratory of New Drug Screening, Educational Department of Jiangxi Province of China [GJJ151075], Natural Science Foundation of Jiangxi Province of China [20161BAB215194] and the Scientific Research Project of Jiujiang University [2015LGYB35].
  • Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. However, antiviral drugs against this infection are not available. To identify novel anti-DENV compound from traditional Chinese medicine, we discovered the ethanol extract of Acorus tatarinowii Schott containing potent anti-DENV activity and diasarone-I was isolated from this extract. Diasarone-I has antiviral effect with half maximal effective concentration (EC50) of 4.5μM and half maximal cytotoxicity concentration (CC50) of >80μM. Time of drug addition assay suggested that this compound inhibited at RNA replication step in the DENV life cycle. Further, in silico analysis indicated that diasarone-I might act as an inhibitor of 2'O Methyltransferase of NS5. Diasarone-I has also decreased the DENV2-induced STAT1 phosphorylation and ISGs. In summary, we suggest that diasarone-I may be a 2'O Methyltransferase inhibitor and might serve as a potential candidate for the treatment of DENV2 infections. © 2017 Elsevier B.V.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Ling, YunDepartment of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China (author)
  • Guo, SongxinSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China (author)
  • He, ShijunSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China (author)
  • Wang, JinanShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China (author)
  • Zhang, QingDepartment of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China (author)
  • Wu, WenyuZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, PR China (author)
  • Zou, MinSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China (author)
  • Zhang, TingtingSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China (author)
  • Nandakumar, Kutty Selva,1965-School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China(Swepub:hh)kutnam (author)
  • Chen, XiaoguangSchool of Public Health, Southern Medical University, Southern Medical University, Guangzhou, PR China (author)
  • Liu, ShuwenSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China (author)
  • School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR ChinaDepartment of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China (creator_code:org_t)

Related titles

  • In:European Journal of PharmacologyAmsterdam : Elsevier821, s. 11-200014-29991879-0712

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