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- Svensson, LarsLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden (author)
IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis
- Article/chapterEnglish2002
Publisher, publication year, extent ...
- Weinheim :Wiley-VCH Verlagsgesellschaft,2002
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:hh-48809
- https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-48809URI
- https://doi.org/10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4DOI
- https://lup.lub.lu.se/record/110833URI
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- Language:English
- Summary in:English
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Notes
- Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Our results show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficient mice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which was promoted by IL-4 deficiency. We conclude that IL-4 plays different roles depending on the type of adjuvant used and the phase (acute or chronic) of the clinical disease.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- Autoantibody
- Autoimmunity
- Rheumatoid arthritis
- Th1/Th2 cell
Added entries (persons, corporate bodies, meetings, titles ...)
- Nandakumar, Kutty Selva,1965-Lund University, Lund, Sweden(Swepub:hh)kutnam (author)
- Johansson, ÅsaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-ajo (author)
- Jansson, LiselotteLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-lja (author)
- Holmdahl, RikardLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-rho (author)
- ImmunologiForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:European Journal of ImmunologyWeinheim : Wiley-VCH Verlagsgesellschaft32:10, s. 2944-29530014-29801521-4141
Internet link
- https://doi.org/10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4Fulltext
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12355448&dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-48809
- https://doi.org/10.1002/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4
- https://lup.lub.lu.se/record/110833
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