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The crystal structu...
The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab : Structure to function analysis
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- Uysal, Hüseyin (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund University, Lund, Sweden
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- Sehnert, Bettina (author)
- Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany
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- Nandakumar, Kutty Selva, 1965- (author)
- Lund University, Lund, Sweden
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- Böiers, Ulrika (author)
- Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany
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- Burkhardt, Harald (author)
- Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany
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- Holmdahl, Rikard (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden
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- Thunnissen, Marjolein M.G.M. (author)
- Lund University, Lund, Sweden
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(creator_code:org_t)
- Oxford : Elsevier, 2008
- 2008
- English.
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In: Molecular Immunology. - Oxford : Elsevier. - 0161-5890 .- 1872-9142. ; 45:8, s. 2196-2204
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic autoantibody, which induces arthritis in mice. We crystallized and solved the structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction between the CDR regions of one Fab to the CH1 domain of another Fab, which resembles an antibody-antigen interaction. ELISA experiments confirmed the cross-reactivity of both the full CIIC1 antibody and a single chain Fv fragment to other anti-collagen antibodies which are of different isotypes and epitope specificity. The rheumatoid factor like reactivity of CIIC1 antibody together with its collagen type II specificity may explain the pathogenicity of this antibody. © 2007 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Arthritis
- Autoantibodies
- Collagen type II
- Rheumatoid factor
Publication and Content Type
- ref (subject category)
- art (subject category)
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