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High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice
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- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden; Department of Clinical Sciences, Lund University, Malmö, Sweden
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- Ekman, Diana (author)
- Karolinska Institute, Stockholm, Sweden
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- Lindvall, Therese (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden
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- Popovic, Marjan (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden
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- Förster, Michael (author)
- Karolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden
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- Hultqvist, Malin (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden
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- Klaczkowska, Dorota (author)
- Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden
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- Teneva, Ivanka (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden
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- Johannesson, Martina (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden; Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
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- Flint, Jonathan (author)
- Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
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- Valdar, William (author)
- University of North Carolina, Chapel Hill, NC, United States
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- Nandakumar, Kutty Selva, 1965- (author)
- Karolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden
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- Holmdahl, Rikard (author)
- Karolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden
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(creator_code:org_t)
- 2011-05-12
- 2011
- English.
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In: Human Molecular Genetics. - Oxford : Oxford University Press. - 0964-6906 .- 1460-2083. ; 20:15, s. 3031-3041
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Abstract
Subject headings
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- Resolving the genetic basis of complex diseases like rheumatoid arthritis will require knowledge of the corresponding diseases in experimental animals to enable translational functional studies. Mapping of quantitative trait loci in mouse models of arthritis, such as collagen-induced arthritis (CIA), using F(2) crosses has been successful, but can resolve loci only to large chromosomal regions. Using an inbred-outbred cross design, we identified and fine-mapped CIA loci on a genome-wide scale. Heterogeneous stock mice were first intercrossed with an inbred strain, B10.Q, to introduce an arthritis permitting MHCII haplotype. Homozygous H2(q) mice were then selected to set up an F(3) generation with fixed major histocompatibility complex that was used for arthritis experiments. We identified 26 loci, 18 of which are novel, controlling arthritis traits such as incidence of disease, severity and time of onset and fine-mapped a number of previously mapped loci. © The Author 2011. Published by Oxford University Press. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- rheumatoid arthritis
- arthritis
- heterogeneity
- genome
- haplotypes
- genetics
- mice
- quantitative trait loci
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ahlqvist, Emma
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Ekman, Diana
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Lindvall, Theres ...
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Popovic, Marjan
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Förster, Michael
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Hultqvist, Malin
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Klaczkowska, Dor ...
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Teneva, Ivanka
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Johannesson, Mar ...
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Flint, Jonathan
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Valdar, William
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Nandakumar, Kutt ...
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Holmdahl, Rikard
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Human Molecular ...
- By the university
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Halmstad University
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Lund University
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Karolinska Institutet