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  • Ahlqvist, EmmaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden; Department of Clinical Sciences, Lund University, Malmö, Sweden (author)

High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-05-12
  • Oxford :Oxford University Press,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:hh-48858
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-48858URI
  • https://doi.org/10.1093/hmg/ddr206DOI
  • https://lup.lub.lu.se/record/2094174URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122921065URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agency: Masterswitch Grant number: HEALTH-F2-2008-223404
  • Resolving the genetic basis of complex diseases like rheumatoid arthritis will require knowledge of the corresponding diseases in experimental animals to enable translational functional studies. Mapping of quantitative trait loci in mouse models of arthritis, such as collagen-induced arthritis (CIA), using F(2) crosses has been successful, but can resolve loci only to large chromosomal regions. Using an inbred-outbred cross design, we identified and fine-mapped CIA loci on a genome-wide scale. Heterogeneous stock mice were first intercrossed with an inbred strain, B10.Q, to introduce an arthritis permitting MHCII haplotype. Homozygous H2(q) mice were then selected to set up an F(3) generation with fixed major histocompatibility complex that was used for arthritis experiments. We identified 26 loci, 18 of which are novel, controlling arthritis traits such as incidence of disease, severity and time of onset and fine-mapped a number of previously mapped loci. © The Author 2011. Published by Oxford University Press. All rights reserved.

Subject headings and genre

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  • Ekman, DianaKarolinska Institute, Stockholm, Sweden (author)
  • Lindvall, ThereseLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-tli (author)
  • Popovic, MarjanLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden(Swepub:lu)med-mpv (author)
  • Förster, MichaelKarolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden(Swepub:lu)med-mhf (author)
  • Hultqvist, MalinLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-mhu (author)
  • Klaczkowska, DorotaKarolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden (author)
  • Teneva, IvankaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)med-itv (author)
  • Johannesson, MartinaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden; Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom(Swepub:lu)infl-mjo (author)
  • Flint, JonathanWellcome Trust Centre for Human Genetics, Oxford, United Kingdom (author)
  • Valdar, WilliamUniversity of North Carolina, Chapel Hill, NC, United States (author)
  • Nandakumar, Kutty Selva,1965-Karolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden(Swepub:lu)infl-nku (author)
  • Holmdahl, RikardKarolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden(Swepub:lu)infl-rho (author)
  • ImmunologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Human Molecular GeneticsOxford : Oxford University Press20:15, s. 3031-30410964-69061460-2083

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