Search: onr:"swepub:oai:DiVA.org:hh-48858" >
High-resolution map...
-
Ahlqvist, EmmaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden; Department of Clinical Sciences, Lund University, Malmö, Sweden
(author)
High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice
- Article/chapterEnglish2011
Publisher, publication year, extent ...
-
2011-05-12
-
Oxford :Oxford University Press,2011
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:hh-48858
-
https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-48858URI
-
https://doi.org/10.1093/hmg/ddr206DOI
-
https://lup.lub.lu.se/record/2094174URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:122921065URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Funding agency: Masterswitch Grant number: HEALTH-F2-2008-223404
-
Resolving the genetic basis of complex diseases like rheumatoid arthritis will require knowledge of the corresponding diseases in experimental animals to enable translational functional studies. Mapping of quantitative trait loci in mouse models of arthritis, such as collagen-induced arthritis (CIA), using F(2) crosses has been successful, but can resolve loci only to large chromosomal regions. Using an inbred-outbred cross design, we identified and fine-mapped CIA loci on a genome-wide scale. Heterogeneous stock mice were first intercrossed with an inbred strain, B10.Q, to introduce an arthritis permitting MHCII haplotype. Homozygous H2(q) mice were then selected to set up an F(3) generation with fixed major histocompatibility complex that was used for arthritis experiments. We identified 26 loci, 18 of which are novel, controlling arthritis traits such as incidence of disease, severity and time of onset and fine-mapped a number of previously mapped loci. © The Author 2011. Published by Oxford University Press. All rights reserved.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ekman, DianaKarolinska Institute, Stockholm, Sweden
(author)
-
Lindvall, ThereseLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-tli
(author)
-
Popovic, MarjanLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden(Swepub:lu)med-mpv
(author)
-
Förster, MichaelKarolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden(Swepub:lu)med-mhf
(author)
-
Hultqvist, MalinLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-mhu
(author)
-
Klaczkowska, DorotaKarolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden
(author)
-
Teneva, IvankaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)med-itv
(author)
-
Johannesson, MartinaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden; Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom(Swepub:lu)infl-mjo
(author)
-
Flint, JonathanWellcome Trust Centre for Human Genetics, Oxford, United Kingdom
(author)
-
Valdar, WilliamUniversity of North Carolina, Chapel Hill, NC, United States
(author)
-
Nandakumar, Kutty Selva,1965-Karolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden(Swepub:lu)infl-nku
(author)
-
Holmdahl, RikardKarolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institute, Stockholm, Sweden; Lund University, Lund, Sweden(Swepub:lu)infl-rho
(author)
-
ImmunologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:Human Molecular GeneticsOxford : Oxford University Press20:15, s. 3031-30410964-69061460-2083
Internet link
Find in a library
To the university's database
- By the author/editor
-
Ahlqvist, Emma
-
Ekman, Diana
-
Lindvall, Theres ...
-
Popovic, Marjan
-
Förster, Michael
-
Hultqvist, Malin
-
show more...
-
Klaczkowska, Dor ...
-
Teneva, Ivanka
-
Johannesson, Mar ...
-
Flint, Jonathan
-
Valdar, William
-
Nandakumar, Kutt ...
-
Holmdahl, Rikard
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Human Molecular ...
- By the university
-
Halmstad University
-
Lund University
-
Karolinska Institutet