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Chronic Active Arth...
Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells : A Novel Experimental Model of Rheumatoid Arthritis
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- Hagert, C. (author)
- University of Turku, Turku, Finland
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- Sareila, O. (author)
- Karolinska Institutet
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- Kelkka, T. (author)
- The National Doctoral Programme in Informational and Structural Biology, Turku, Finland; University of Turku, Turku, Finland
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- Nandakumar, Kutty Selva, 1965- (author)
- Karolinska Institutet
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- Collin, Mattias (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infektion och immunmodulering,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Infection and immunomodulation,Lund University Research Groups,Lund University, Lund, Sweden
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- Xu, B. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Institute, Stockholm, Sweden
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- Guerard, S. (author)
- Karolinska Institute,Karolinska Institute, Stockholm, Sweden
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- Bäcklund, Johan (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Institute, Stockholm, Sweden
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- Jalkanen, S. (author)
- University of Turku, Turku, Finland
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- Holmdahl, Rikard (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2018-06-20
- 2018
- English.
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In: Arthritis & Rheumatology. - Hoboken : Wiley. - 2326-5191 .- 2326-5205 .- 1529-0131. ; 70:8, s. 1343-1353
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- OBJECTIVE: To develop a new chronic rheumatoid arthritis model that is driven by the innate immune system. METHODS: Injection of a cocktail of 4 monoclonal antibodies against type II collagen, followed on days 5 and 60 by intraperitoneal injections of mannan (from Saccharomyces cerevisiae), was used to induce development of chronic arthritis in B10.Q mice. The role of the innate immune system as compared to the adaptive immune system in this arthritis model was investigated using genetically modified mouse strains. RESULTS: A new model of chronic relapsing arthritis was characterized in B10.Q mice, in which a persistently active, chronic disease was found. This relapsing disease was driven by macrophages lacking the ability to mount a reactive oxygen species response against pathogens, and was associated with the classical/alternative pathway, but not the lectin pathway, of complement activation. The disease was independent of Fcgamma receptor type III, and also independent of the activity of adaptive immune cells (B and T cells), indicating that the innate immune system, involving complement activation, could be the sole driver of chronicity. CONCLUSION: Chronic active arthritis can be driven innately by macrophages without the involvement of T and B cells in the adaptive immune system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Animals
- Antibodies
- Monoclonal/immunology
- Arthritis
- Experimental/*immunology
- Arthritis
- Rheumatoid/*immunology
- B-Lymphocytes/immunology
- Collagen Type II/immunology
- Disease Models
- Animal
- Immunity
- Innate/*immunology
- Macrophages/*immunology
- Mice
- T-Lymphocytes/*immunology
- Journal Article
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Hagert, C.
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Sareila, O.
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Kelkka, T.
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Nandakumar, Kutt ...
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Collin, Mattias
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Xu, B.
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Guerard, S.
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Bäcklund, Johan
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Jalkanen, S.
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Holmdahl, Rikard
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Arthritis & Rheu ...
- By the university
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Halmstad University
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Lund University
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Karolinska Institutet