Decreasing incidence of peptic ulcer complications after the introduction of the proton pump inhibitors, a study of the Swedish population from 1974-2002.

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Hermansson, MichaelDepartment of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden (author)

Decreasing incidence of peptic ulcer complications after the introduction of the proton pump inhibitors, a study of the Swedish population from 1974-2002.

Article/chapterEnglish2009

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BioMed Central,2009
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:hik-2149
https://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2149URI
https://doi.org/10.1186/1471-230X-9-25DOI
https://lup.lub.lu.se/record/1444085URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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BACKGROUND: Despite a decreasing incidence of peptic ulcer disease, most previous studies report a stabile incidence of ulcer complications. We wanted to investigate the incidence of peptic ulcer complications in Sweden before and after the introduction of the proton pump inhibitors (PPI) in 1988 and compare these data to the sales of non-steroid anti-inflammatory drugs (NSAID) and acetylsalicylic acid (ASA).METHODS: All cases of gastric and duodenal ulcer complications diagnosed in Sweden from 1974 to 2002 were identified using the National hospital discharge register. Information on sales of ASA/NSAID was obtained from the National prescription survey. RESULTS: When comparing the time-periods before and after 1988 we found a significantly lower incidence of peptic ulcer complications during the later period for both sexes (p < 0.001). Incidence rates varied from 1.5 to 7.8/100000 inhabitants/year regarding perforated peptic ulcers and from 5.2 to 40.2 regarding peptic ulcer bleeding. The number of sold daily dosages of prescribed NSAID/ASA tripled from 1975 to 2002. The number of prescribed sales to women was higher than to males. Sales of low-dose ASA also increased. The total volume of NSAID and ASA, i.e. over the counter sale and sold on prescription, increased by 28% during the same period.CONCLUSION: When comparing the periods before and after the introduction of the proton pump inhibitors we found a significant decrease in the incidence of peptic ulcer complications in the Swedish population after 1988 when PPI were introduced on the market. The cause of this decrease is most likely multifactorial, including smoking habits, NSAID consumption, prevalence of Helicobacter pylori and the introduction of PPI. Sales of prescribed NSAID/ASA increased, especially in middle-aged and elderly women. This fact seems to have had little effect on the incidence of peptic ulcer complications.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Samhällsfarmaci och klinisk farmaci hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Social and Clinical Pharmacy hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Community pharmacy services
Samhällsfarmaci
Natural Science
Naturvetenskap
Pharmacology
Farmakologi

Added entries (persons, corporate bodies, meetings, titles ...)

Ekedahl, Anders,1949-Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Department of Community Health Sciences, Lund University, Malmö, Sweden(Swepub:lu)smi-aek (author)
Ranstam, JonasLund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,NKO, Lund University Hospital, Lund(Swepub:lu)ort-jra (author)
Zilling, ThomasLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Surgery, Varberg Hospital, Sweden(Swepub:lu)kir-tzi (author)
Department of Surgery, Sahlgrenska University Hospital, Gothenburg, SwedenKardiovaskulär forskning - epidemiologi (creator_code:org_t)

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In:BMC Gastroenterology: BioMed Central9:April, s. Article number: 25-1471-230X

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