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Adding high-intensi...
Adding high-intensity interval training to conventional training modalities : optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial
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- Mijwel, Sara (author)
- Karolinska Institutet
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- Backman, Malin (author)
- Karolinska Institutet
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- Bolam, Kate (author)
- Karolinska Institutet
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- Jervaeus, Anna (author)
- Karolinska Institutet
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- Sundberg, Carl Johan (author)
- Karolinska Institutet
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- Margolin, Sara (author)
- Karolinska Institutet
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- Browall, Maria (author)
- Jönköping University,Högskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden,Välbefinnande vid långvariga hälsoproblem, Wellbeing in long-term health problems (WeLHP),HHJ, Avdelningen för omvårdnad,HHJ. IMPROVE (Improvement, innovation, and leadership in health and welfare),Högskolan i Skövde, Institutionen för hälsa och lärande
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- Rundqvist, Helene (author)
- Karolinska Institutet
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- Wengström, Yvonne (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2017-11-14
- 2018
- English.
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In: Breast Cancer Research and Treatment. - : Springer. - 0167-6806 .- 1573-7217. ; 168:1, s. 79-93
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Abstract
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- PURPOSE: Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT-HIIT), and moderate-intensity aerobic and high-intensity interval training (AT-HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.METHODS: Two hundred and forty women planned to undergo chemotherapy were randomized to supervised RT-HIIT, AT-HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.RESULTS: The RT-HIIT group was superior to UC for CRF: total CRF (p = 0.02), behavior/daily life (p = 0.01), and sensory/physical (p = 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT-HIIT compared to declines shown in the UC group (p = 0.04). AT-HIIT significantly improved emotional functioning versus UC (p = 0.01) and was superior to UC for pain symptoms (p = 0.03). RT-HIIT reported a reduced symptom burden, while AT-HIIT remained stable compared to deteriorations shown by UC (p < 0.01). Only RT-HIIT was superior to UC for total symptoms (p < 0.01).CONCLUSIONS: 16 weeks of resistance and HIIT was effective in preventing increases in CRF and in reducing symptom burden for patients during chemotherapy for breast cancer. These findings add to a growing body of evidence supporting the inclusion of structured exercise prescriptions, including HIIT, as a vital component of cancer rehabilitation.TRIAL REGISTRATION: Clinicaltrials.gov Registration Number: NCT02522260.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast cancer
- Chemotherapy
- Concurrent training
- Health-related quality of life
- High-intensity interval training
- Symptom burden
- Wellbeing in long-term health problems (WeLHP)
- Välbefinnande vid långvariga hälsoproblem (WeLHP)
Publication and Content Type
- ref (subject category)
- art (subject category)
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