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Body mass index and...
Body mass index and risk of dementia : Analysis of individual-level data from 1.3 million individuals
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- Kivimäki, Mika (author)
- Department of Epidemiology and Public Health, University College London, London, United Kingdom / Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland / Finnish Institute of Occupational Health, Helsinki and Turku, Finland
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- Luukkonen, Ritva (author)
- Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Batty, G. David (author)
- Department of Epidemiology and Public Health, University College London, London, United Kingdom / Centre for Cognitive Ageing and Cognitive Epidemiology, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom
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- Ferrie, Jane E. (author)
- School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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- Pentti, Jaana (author)
- Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland / Finnish Institute of Occupational Health, Helsinki and Turku, Finland
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- Theorell, Töres (author)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet
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- Shipley, Martin J. (author)
- Department of Epidemiology and Public Health, University College London, London, United Kingdom
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- Alfredsson, Lars (author)
- Karolinska Institutet
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- Fransson, Eleonor I. (author)
- Stockholms universitet,Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. ADULT,HHJ. ARN-J (Aging Research Network - Jönköping),Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden / School of Health Sciences and Welfare, Jönköping University, Jönköping, Sweden / Division of Epidemiology, Stress Research Institute, Stockholm University, Stockholm,Stressforskningsinstitutet
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- Goldberg, Marcel (author)
- Population-based Epidemiologic Cohort Unit, UMS 011, Inserm, Villejuif, France
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- Knutsson, Anders, 1942- (author)
- Mittuniversitetet,Avdelningen för hälsovetenskap,Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden
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- Koskenvuo, Markku (author)
- Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Kuosma, Eeva (author)
- Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Nordin, Maria (author)
- Stockholms universitet,Umeå universitet,Institutionen för psykologi,Division of Epidemiology, Stress Research Institute, Stockholm University, Stockholm, Sweden / Department of Psychology, Umeå University, Umeå, Sweden,Stockholm University, Stockholm; Umeå University, Umeå,Stressforskningsinstitutet
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- Suominen, Sakari (author)
- Högskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Folkhälsan Research Center, Folkhälsan, Helsinki, Finland; University of Skövde, Skövde; Turku University Hospital, Turku, Finland,Individ och samhälle, Individual and Society (VIDSOC)
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- Theorell, Töres (author)
- Division of Epidemiology, Stress Research Institute, Stockholm University, Stockholm, Sweden
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- Vuoksimaa, Eero (author)
- Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland / Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland
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- Westerholm, Peter (author)
- Uppsala universitet,Arbets- och miljömedicin
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- Westerlund, Hugo (author)
- Stockholms universitet,Stressforskningsinstitutet
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- Zins, Marie (author)
- Population-based Epidemiologic Cohort Unit, UMS 011, Inserm, Villejuif, France
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- Kivipelto, Miia (author)
- Karolinska Institutet
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- Vahtera, Jussi (author)
- Turku University Hospital, Turku, Finland / University of Turku, Turku, Finland
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- Kaprio, Jaakko (author)
- Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland / Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland
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- Singh-Manoux, Archana (author)
- Umeå universitet,Institutionen för psykologi,Department of Epidemiology and Public Health, University College London, London, UK; Population-based Epidemiologic Cohort Unit, UMS 011, Inserm, Villejuif, France,Department of Epidemiology and Public Health, University College London, London, United Kingdom / Population-based Epidemiologic Cohort Unit, France / Department of Psychology, Umeå University, Umeå, Sweden
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- Jokela, Markus (author)
- Umeå universitet,Institutionen för psykologi,Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland / Department of Psychology, Umeå University, Umeå, Sweden
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(creator_code:org_t)
- 2017-11-20
- 2018
- English.
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In: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 14:5, s. 601-609
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Introduction: Higher midlife body mass index (BMI) is suggested to increase the risk of dementia, but weight loss during the preclinical dementia phase may mask such effects. Methods: We examined this hypothesis in 1,349,857 dementia-free participants from 39 cohort studies. BMI was assessed at baseline. Dementia was ascertained at follow-up using linkage to electronic health records (N = 6894). We assumed BMI is little affected by preclinical dementia when assessed decades before dementia onset and much affected when assessed nearer diagnosis. Results: Hazard ratios per 5-kg/m(2) increase in BMI for dementia were 0.71 (95% confidence interval = 0.66-0.77), 0.94 (0.89-0.99), and 1.16 (1.05-1.27) when BMI was assessed 10 years, 10-20 years, and >20 years before dementia diagnosis. Conclusions: The association between BMI and dementia is likely to be attributable to two different processes: a harmful effect of higher BMI, which is observable in long follow-up, and a reverse-causation effect that makes a higher BMI to appear protective when the follow-up is short. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- body mass index
- dementia
- cohort study
- bias
- obesity
- Individual and Society VIDSOC
- Individ och samhälle VIDSOC
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kivimäki, Mika
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Luukkonen, Ritva
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Batty, G. David
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Ferrie, Jane E.
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Pentti, Jaana
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Theorell, Töres
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Shipley, Martin ...
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Alfredsson, Lars
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Fransson, Eleono ...
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Goldberg, Marcel
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Knutsson, Anders ...
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Koskenvuo, Markk ...
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Kuosma, Eeva
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Nordin, Maria
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Suominen, Sakari
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Vuoksimaa, Eero
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Westerholm, Pete ...
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Westerlund, Hugo
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Zins, Marie
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Kivipelto, Miia
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Vahtera, Jussi
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Kaprio, Jaakko
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Singh-Manoux, Ar ...
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Jokela, Markus
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
- Articles in the publication
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Alzheimer's & De ...
- By the university
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University of Skövde
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Umeå University
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Mid Sweden University
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Jönköping University
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Stockholm University
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Karolinska Institutet
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Uppsala University
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