Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling : a case study for blood brain barrier research in a pharmaceutical setting

• Microphysiological systems (MPS) may be able to provide the pharmaceutical industry models that can reflect human physiological responses to improve drug discovery and translational outcomes. With lack of efficacy being the primary cause for drug attrition, developing MPS disease models would help researchers identify novel targets, study mechanisms in more physiologically-relevant depth, screen for novel biomarkers and test/optimize various therapeutics (small molecules, nanoparticles and biologics). Furthermore, with advances in inducible pluripotent stem cell technology (iPSC), pharmaceutical companies can access cells from patients to help recreate specific disease phenotypes in MPS platforms. Combining iPSC and MPS technologies will contribute to our understanding of the complexities of neurodegenerative diseases and of the blood brain barrier (BBB) leading to development of enhanced therapeutics. © 2018

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Keyword

Blood brain barrier

Drug development

iPSC

Microphysiological systems

Organs-on-chips

Pharmaceutical

Stem cells

Tissue chips

Blood

Drug products

Neurodegenerative diseases

Blood-brain barrier

Induced pluripotent stem cells

On chips

Pharmaceutical company

Pharmaceutical industry

Physiological response

Physiological models

Bioinformatik

Bioinformatics

INF502 Biomarkers

INF502 Biomarkörer

Microphysiological systems

Organs-on-chips

Tissue chips

Stem cells

iPSC

Blood brain barrier

Pharmaceutical

Drug development

in-vitro model

drug discovery

efficient generation

endothelial-cells

cns

differentiation

inflammation

permeability

penetration

crispr/cas9

Pharmacology & Pharmacy

Publication and Content Type

ref (subject category)

art (subject category)