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The influence of de...
The influence of dexmedetomidine and propofol on circulating cytokine levels in healthy subjects
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- Kallioinen, Minna (author)
- Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland
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- Scheinin, Annalotta (author)
- Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland
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- Maksimow, Mikael (author)
- Medicity Research Laboratory, University of Turku, Finland
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- Långsjö, Jaakko (author)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland / Department of Intensive Care, Tampere University Hospital, Finland
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- Kaisti, Kaike (author)
- Turku PET Centre, University of Turku and Turku University Hospital, Finland / Department of Anesthesiology and Intensive Care, Oulu University Hospital, Finland
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- Takala, Riikka (author)
- Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland
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- Vahlberg, Tero (author)
- Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Finland
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- Valli, Katja, 1973- (author)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Centre, University of Turku, Finland,Kognitiv neurovetenskap och filosofi, Consciousness and Cognitive Neuroscience
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- Salmi, Marko (author)
- Medicity Research Laboratory, University of Turku, Finland / Institute of Biomedicine, University of Turku, Finland
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- Scheinin, Harry (author)
- Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland / Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Finland
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- Maksimow, Anu (author)
- Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland
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(creator_code:org_t)
- 2019-12-05
- 2019
- English.
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In: BMC Anesthesiology. - : BioMed Central. - 1471-2253 .- 1471-2253. ; 19:1, s. 1-8
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Abstract
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- Background: Surgery and diseases modify inflammatory responses and the immune system. Anesthetic agents also have effects on the human immune system but the responses they induce may be altered or masked by the surgical procedures or underlying illnesses. The aim of this study was to assess how single-drug dexmedetomidine and propofol anesthesia without any surgical intervention alter acute immunological biomarkers in healthy subjects. Methods: Thirty-five healthy, young male subjects were anesthetized using increasing concentrations of dexmedetomidine (n = 18) or propofol (n = 17) until loss of responsiveness (LOR) was detected. The treatment allocation was randomized. Multi-parametric immunoassays for the detection of 48 cytokines, chemokines and growth factors were used. Concentrations were determined at baseline and at the highest drug concentration for each subject. Results: The changes in the concentration of eotaxin (decrease after dexmedetomidine) and platelet-derived growth factor (PDGF, increase after propofol) were statistically significantly different between the groups. Significant changes were detected within both groups; the concentrations of monocyte chemotactic protein 1, chemokine ligand 27 and macrophage migration inhibitory factor were lower in both groups after the drug administration. Dexmedetomidine decreased the concentration of eotaxin, interleukin-18, interleukin-2Ra, stem cell factor, stem cell growth factor and vascular endothelial growth factor, and propofol decreased significantly the levels of hepatocyte growth factor, IFN-.-induced protein 10 and monokine induced by IFN-gamma, and increased the levels of interleukin-17, interleukin-5, interleukin-7 and PDGF. Conclusions: Dexmedetomidine seemed to have an immunosuppressive effect on the immune system whereas propofol seemed to induce mixed pro- and anti-inflammatory effects on the immune system. The choice of anesthetic agent could be relevant when treating patients with compromised immunological defense mechanisms. Trial registration: Before subject enrollment, the study was registered in the European Clinical Trials database (EudraCT number 2013-001496-21, The Neural Mechanisms of Anesthesia and Human Consciousness) and in ClinicalTrials.gov (Principal Investigator: Harry Scheinin, number NCT01889004, The Neural Mechanisms of Anesthesia and Human Consciousness, Part 2, on the 23rd of June 2013).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Övrig annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Other Medical and Health Sciences not elsewhere specified (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Dexmedetomidine
- Propofol
- Immunology
- Immunosuppression
- Cytokines
- Consciousness and Cognitive Neuroscience
- Kognitiv neurovetenskap och filosofi
Publication and Content Type
- ref (subject category)
- art (subject category)
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Kallioinen, Minn ...
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Scheinin, Annalo ...
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Maksimow, Mikael
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Långsjö, Jaakko
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Kaisti, Kaike
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Takala, Riikka
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Vahlberg, Tero
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Valli, Katja, 19 ...
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Salmi, Marko
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Scheinin, Harry
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Maksimow, Anu
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University of Skövde