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Serum amyloid A – A...
Serum amyloid A – A prime candidate for identification of neonatal sepsis
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- Bengnér, Johannes (author)
- Paediatric Clinic, Ryhov County Hospital, Jönköping, Region Jönköping County, Sweden,Länssjukhuset Ryhov,County Hospital Ryhov
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- Quttineh, Maysae (author)
- Department of Laboratory Medicine, Jönköping, Region Jönköping County, Sweden,Region Jönköpings län
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- Gäddlin, Per-Olof (author)
- Paediatric Clinic, Ryhov County Hospital, Jönköping, Region Jönköping County, Sweden,Länssjukhuset Ryhov,County Hospital Ryhov
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- Salomonsson, Kent (author)
- Högskolan i Skövde,Institutionen för ingenjörsvetenskap,Forskningsmiljön Virtuell produkt- och produktionsutveckling,Virtual Manufacturing Processes,Virtual Engineering Research Environment, School of Engineering Science, University of Skövde, Skövde, Sweden,University of Skövde
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- Faresjö, Maria (author)
- Jönköping University,HHJ, Avdelningen för klinisk diagnostik,HHJ. Biomedicinsk plattform,Biomedical Platform, Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Sweden ; Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: Clinical Immunology. - : Elsevier. - 1521-6616 .- 1521-7035. ; 229:108787
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Abstract
Subject headings
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- Neonatal sepsis is common, lethal, and hard to diagnose. In combination with clinical findings and blood culture, biomarkers are crucial to make the correct diagnose. A Swedish national inquiry indicated that neonatologists were not quite satisfied with the available biomarkers. We assessed the kinetics of 15 biomarkers simultaneously: ferritin, fibrinogen, granulocyte colony-stimulating factor (G-CSF), interferon (IFN)-γ, interleukin (IL)-1β, −6, −8, −10, macrophage inflammatory protein (MIP)-1β, procalcitonin, resistin, serum amyloid A (SAA), tumor necrosis factor (TNF)-α, tissue plasminogen activator-3 and visfatin. The goal was to observe how quickly they rise in response to infection, and for how long they remain elevated. From a neonatal intensive care unit, newborns ≥28 weeks gestational age were recruited. Sixty-eight newborns were recruited to the study group (SG), and fifty-one to the control group (CG). The study group subjects were divided into three subgroups depending on clinical findings: confirmed sepsis (CSG), suspected sepsis (SSG) and no sepsis. CSG and SSG were also merged into an entire sepsis group (ESG) for sub-analysis. Blood samples were collected at three time-points; 0 h, 12–24 h and 48–72 h, in order to mimic a “clinical setting”. At 0 h, visfatin was elevated in SSG compared to CG; G-CSF, IFN-γ, IL-1β, −8 and − 10 were elevated in SSG and ESG compared to CG, whereas IL-6 and SAA were elevated in all groups compared to CG. At 12–24 h, IL-8 was elevated in ESG compared to CG, visfatin was elevated in ESG and SSG compared to CG, and SAA was elevated in all three groups compared to CG. At 48–72 h, fibrinogen was elevated in ESG compared to CG, IFN-γ and IL-1β were elevated in SSG and ESG compared to CG, whereas IL-8 and SAA were elevated in all three groups compared to CG. A function of time-formula is introduced as a tool for theoretical prediction of biomarker levels at any time-point. We conclude that SAA has the most favorable kinetics regarding diagnosing neonatal sepsis, of the biomarkers studied. It is also readily available methodologically, making it a prime candidate for clinical use.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Keyword
- Biomarkers
- Function of time
- Kinetics
- Neonatal
- Sepsis
- Serum amyloid A
- Virtual Manufacturing Processes
- Virtual Manufacturing Processes
Publication and Content Type
- ref (subject category)
- art (subject category)
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