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Vitamin D supplemen...
Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial : a randomized controlled trial
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- Virtanen, Jyrki K. (author)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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- Nurmi, Tarja (author)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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- Aro, Antti (author)
- Independent scientist, Kangasala, Finland
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- Bertone-Johnson, Elizabeth R. (author)
- Departmentof Biostatistics, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA ; Department of Epidemiology and HealthPromotion and Policy, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA
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- Hyppönen, Elina (author)
- Australian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, Australia ; South Australian Health and Medical Research Institute, Adelaide, Australia
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- Kröger, Heikki (author)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland ; Department of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland
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- Lamberg-Allardt, Christel (author)
- Department of Food andNutrition, University of Helsinki, Finland
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- Manson, JoAnn E. (author)
- Department of Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, MA, USA ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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- Mursu, Jaakko (author)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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- Mäntyselkä, Pekka (author)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland ; Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland
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- Suominen, Sakari (author)
- Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Public Health, University of Turku, Finland,Medborgarcentrerad hälsa (MeCH), Research on Citizen Centered Health, University of Skövde (Reacch US)
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- Uusitupa, Matti (author)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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- Voutilainen, Ari (author)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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- Tuomainen, Tomi-Pekka (author)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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- Hantunen, Sari (author)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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(creator_code:org_t)
- Oxford University Press, 2022
- 2022
- English.
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In: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 115:5, s. 1300-1310
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Abstract
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- BACKGROUND: Vitamin D insufficiency is associated with risk of cardiovascular diseases (CVD) and cancer in observational studies, but evidence for benefits with vitamin D supplementation is limited.OBJECTIVES: To investigate the effects of vitamin D3 supplementation on CVD and cancer incidence.DESIGN: The study was a 5-year randomized placebo-controlled trial among 2495 male participants ≥ 60 years and post-menopausal female participants ≥ 65 years from a general Finnish population who were free of prior CVD or cancer. The study had three arms: placebo, 1600 IU/day or 3200 IU/day vitamin D3. Follow-up was by annual study questionnaires and national registry data. A representative sub-cohort of 551 participants had more detailed in-person investigations. The primary endpoints were incident major CVD and invasive cancer. Secondary endpoints included the individual components of the primary CVD endpoint (myocardial infarction, stroke, and CVD mortality), site-specific cancers and cancer death.RESULTS: During the follow-up, there were 41 (4.9%), 42 (5.0%) and 36 (4.3%) major CVD events in the placebo, 1600 IU/d (vs. placebo: hazard ratio (HR), 0.97;95% CI, 0.63,1.49; P = 0.89), and 3200 IU/d (HR, 0.84;95% CI, 0.54,1.31; P = 0.44) arms, respectively. Invasive cancer was diagnosed in 41 (4.9%), 48 (5.8%) and 40 (4.8%) participants in the placebo, 1600 IU/d (HR, 1.14;95% CI, 0.75,1.72; P = 0.55), and 3200 IU/d (HR, 0.95;95% CI, 0.61,1.47; P = 0.81) arms, respectively. There were no significant differences in the secondary endpoints or total mortality. In the sub-cohort, the mean (standard deviation) baseline serum 25-hydroxyvitamin D concentration was 75 (18) nmol/L. After 12 months, the concentrations were 73 (18) nmol/L, 100 (21) nmol/L and 120 (22) nmol/L in the placebo, 1600 IU/d and 3200 IU/d arms, respectively.CONCLUSIONS: Vitamin D3 supplementation did not lower the incidence of major CVD events or invasive cancer among older adults, possibly due to sufficient vitamin D status in most participants at baseline. Clinical Trial Registry number: ClinicalTrials.gov: NCT01463813, https://clinicaltrials.gov/ct2/show/NCT01463813.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- cancer
- cardiovascular disease
- elderly
- randomized controlled trial
- supplementation study
- vitamin d
- Research on Citizen Centered Health, University of Skövde (Reacch US)
- Medborgarcentrerad hälsa (Mech)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Virtanen, Jyrki ...
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Nurmi, Tarja
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Aro, Antti
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Bertone-Johnson, ...
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Hyppönen, Elina
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Kröger, Heikki
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Lamberg-Allardt, ...
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Manson, JoAnn E.
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Mursu, Jaakko
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Mäntyselkä, Pekk ...
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Suominen, Sakari
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Uusitupa, Matti
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Voutilainen, Ari
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Tuomainen, Tomi- ...
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Hantunen, Sari
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University of Skövde