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Proteomics reveal b...
Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis
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- Åkesson, Julia (author)
- Linköpings universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Bioinformatics, Department of Physics, Chemistry and Biology, Linköping University, Sweden,Translationell bioinformatik, Translational bioinformatics,Bioinformatik,Tekniska fakulteten,Systems Biology Research Centre, School of Bioscience, University of Skövde, Skövde, Sweden
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- Hojjati, Sara, 1994- (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Hellberg, Sandra, 1986- (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Raffetseder, Johanna, 1984- (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Khademi, Mohsen (author)
- Karolinska Institutet,Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
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- Rynkowski, Robert (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping
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- Kockum, Ingrid (author)
- Karolinska Institutet,Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
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- Altafini, Claudio, 1969- (author)
- Linköpings universitet,Reglerteknik,Tekniska fakulteten
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- Lubovac-Pilav, Zelmina (author)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translationell bioinformatik, Translational bioinformatics,Systems Biology Research Centre, School of Bioscience, University of Skövde, Skövde, Sweden
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- Mellergård, Johan, 1974- (author)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping
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- Jenmalm, Maria, 1971- (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Piehl, Fredrik (author)
- Karolinska Institutet,Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
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- Olsson, Tomas (author)
- Karolinska Institutet,Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
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- Ernerudh, Jan, 1952- (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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- Gustafsson, Mika, 1977- (author)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
- Related links:
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https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Sensitive and reliable protein biomarkers are needed to predict disease trajectory and personalize treatment strategies for multiple sclerosis (MS). Here, we use the highly sensitive proximity-extension assay combined with next-generation sequencing (Olink Explore) to quantify 1463 proteins in cerebrospinal fluid (CSF) and plasma from 143 people with early-stage MS and 43 healthy controls. With longitudinally followed discovery and replication cohorts, we identify CSF proteins that consistently predicted both short- and long-term disease progression. Lower levels of neurofilament light chain (NfL) in CSF is superior in predicting the absence of disease activity two years after sampling (replication AUC = 0.77) compared to all other tested proteins. Importantly, we also identify a combination of 11 CSF proteins (CXCL13, LTA, FCN2, ICAM3, LY9, SLAMF7, TYMP, CHI3L1, FYB1, TNFRSF1B and NfL) that predict the severity of disability worsening according to the normalized age-related MS severity score (replication AUC = 0.90). The identification of these proteins may help elucidate pathogenetic processes and might aid decisions on treatment strategies for persons with MS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Keyword
- Bioinformatik
- Bioinformatics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Åkesson, Julia
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Hojjati, Sara, 1 ...
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Hellberg, Sandra ...
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Raffetseder, Joh ...
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Khademi, Mohsen
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Rynkowski, Rober ...
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show more...
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Kockum, Ingrid
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Altafini, Claudi ...
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Lubovac-Pilav, Z ...
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Mellergård, Joha ...
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Jenmalm, Maria, ...
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Piehl, Fredrik
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Olsson, Tomas
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Ernerudh, Jan, 1 ...
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Gustafsson, Mika ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
- Articles in the publication
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Nature Communica ...
- By the university
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University of Skövde
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Karolinska Institutet
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Linköping University