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Nightmares share ge...
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Ollila, Hanna M.Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States ; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
(author)
Nightmares share genetic risk factors with sleep and psychiatric traits
- Article/chapterEnglish2024
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Springer Nature,2024
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LIBRIS-ID:oai:DiVA.org:his-23647
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23647URI
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https://doi.org/10.1038/s41398-023-02637-6DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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CC BY 4.0 DEED© The Author(s) 2024Correspondence Address: R. Saxena; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States; email: rsaxena@broadinstitute.org; T. Paunio; Population Health, Finnish Institute for Health and Welfare, Helsinki, Finland; email: tiina.paunio@helsinki.fiThis study has been supported by the Academy of Finland grants #309643 Ollila,#290039 Paunio, Hospital grant (EVO) TYH2019315 Paunio, and the CSC. The NIH R01DK107859 grant and MGH Research Scholar Award were used to support Saxena; a Department of Defense through a National Defense Science and Engineering Grant and a Stanford Graduate Fellowship for Nasa Sinnott-Armstrong, HC has been supported by Finska Läkaresällskapet. JK has been supported by the Academy of Finland (grants 265240, 263278, 308248, 312073, and 336823). Support for genotyping in the Finnish Twin Cohort has been provided by ENGAGE – European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007, grant agreement number 201413 and Wellcome Trust Sanger Institute.
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Nightmares are vivid, extended, and emotionally negative or negative dreams that awaken the dreamer. While sporadic nightmares and bad dreams are common and generally harmless, frequent nightmares often reflect underlying pathologies of emotional regulation. Indeed, insomnia, depression, anxiety, or alcohol use have been associated with nightmares in epidemiological and clinical studies. However, the connection between nightmares and their comorbidities are poorly understood. Our goal was to examine the genetic risk factors for nightmares and estimate correlation or causality between nightmares and comorbidities. We performed a genome-wide association study (GWAS) in 45,255 individuals using a questionnaire-based assessment on the frequency of nightmares during the past month and genome-wide genotyping data. While the GWAS did not reveal individual risk variants, heritability was estimated at 5%. In addition, the genetic correlation analysis showed a robust correlation (rg > 0.4) of nightmares with anxiety (rg = 0.671, p = 7.507e−06), depressive (rg = 0.562, p = 1.282e−07) and posttraumatic stress disorders (rg = 0.4083, p = 0.0152), and personality trait neuroticism (rg = 0.667, p = 4.516e−07). Furthermore, Mendelian randomization suggested causality from insomnia to nightmares (beta = 0.027, p = 0.0002). Our findings suggest that nightmares share genetic background with psychiatric traits and that insomnia may increase an individual’s liability to experience frequent nightmares. Given the significant correlations with psychiatric and psychological traits, it is essential to grow awareness of how nightmares affect health and disease and systematically collect information about nightmares, especially from clinical samples and larger cohorts.
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Sinnott-Armstrong, NasaDepartment of Genetics, School of Medicine, Stanford University, CA, United States
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Kantojärvi, KatriPopulation Health, Finnish Institute for Health and Welfare, Helsinki, Finland ; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Finland
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Broberg, MartinInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
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Palviainen, TeemuInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
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Jones, SamuelInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
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Ripatti, ViliInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
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Pandit, AnitaDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, United States
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Rong, RobinDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, United States
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Kristiansson, KatiPopulation Health, Finnish Institute for Health and Welfare, Helsinki, Finland
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Sandman, NilsDepartment of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland
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Valli, Katja,1973-Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland,Kognitiv Neurovetenskap och Filosofi, Consciousness and Cognitive Neuroscience(Swepub:his)vala
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Hublin, ChristerFinnish Institute of Occupational Health, Helsinki, Finland
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Ripatti, SamuliInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States ; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States
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Widen, ElisabethInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
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Kaprio, JaakkoInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
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Saxena, RichaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States ; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States ; Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States
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Paunio, TiinaPopulation Health, Finnish Institute for Health and Welfare, Helsinki, Finland ; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Finland
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Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States ; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesDepartment of Genetics, School of Medicine, Stanford University, CA, United States
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In:Translational Psychiatry: Springer Nature14:12158-3188
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