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Overexpression of I...
Overexpression of Id-1 protein is a marker in colorectal cancer progression
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- Zhao, Zeng-Ren (author)
- Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China,Department of General Surgery Hebei Medical University, Shijiazhuang 050031, P.R. China
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- Zhang, Hong, 1957- (author)
- Linköpings universitet,Hälsouniversitetet,Dermatologi och venerologi
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- Zhang, Hong (author)
- Department of Dermatology, Institute of Biomedicine and Surgery, Linköping University, Linköping, Sweden
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- Jiang, Li (author)
- Department of Pathology Tangshan Gongren Hospital, Tangshan 063000, P.R. China
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- Wang, Ming-Wei (author)
- Laboratory Centre, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China,Laboratory Centre Hebei Medical University, Shijiazhuang 050031, P.R. China
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- Sun, Xiao-Feng, 1959- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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- Zhang, Zhiyong, 1970- (author)
- Linköpings universitet,Hälsouniversitetet,Onkologi
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Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, PR. China Department of General Surgery Hebei Medical University, Shijiazhuang 050031, P.R. China (creator_code:org_t)
- 2008-02-01
- 2008
- English.
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In: Oncology Reports. - : Spandidos. - 1021-335X .- 1791-2431. ; 19:2, s. 419-424
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http://www.ncbi.nlm....
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Abstract
Subject headings
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- Abstract: The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an important role in the regulation of cell proliferation and differentiation. We examined the Id-1 expression by immunohistochemistry in 9 adenomas, 79 primary colorectal adenocarcinomas matched with 40 adjacent normal mucosa specimens and its relationship with clinicopathological factors. The Id-1 expression was increased in the carcinoma compared to the adjacent normal mucosa either in the unmatched and matched samples or to the adenoma. There was no significant difference in the Id-1 expression between normal mucosa and adenoma. The Id-1 expression of carcinoma was increased from Dukes' stages A to B, to C and to D. The cases with lymph node metastasis had a higher rate of a stronger Id-1 expression than those without lymph node metastasis. In conclusion, Id-1 overexpression plays an important role in colorectal cancer progression.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Cell and molecular biology
- Cell- och molekylärbiologi
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhao, Zeng-Ren
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Zhang, Hong, 195 ...
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Zhang, Hong
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Jiang, Li
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Wang, Ming-Wei
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Sun, Xiao-Feng, ...
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Zhang, Zhiyong, ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Oncology Reports
- By the university
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University of Skövde
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Linköping University