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Dynamic modelling o...
Dynamic modelling of cell death during biofilm development
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- Fagerlind, Magnus G. (author)
- Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi
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- Webb, Jeremy S. (author)
- Univ Southampton, Sch Biol Sci, Southampton SO16 7PX, Hants, England
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- Barraud, Nicolas (author)
- Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia / Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia
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- McDougald, Diane (author)
- Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia / Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia / Nanyang Technol Univ, Adv Environm Biotechnol Ctr, Singapore 639798, Singapore
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- Jansson, Andreas (author)
- Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi
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- Nilsson, Patric (author)
- Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi
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- Harlen, Mikael (author)
- Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi
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- Kjelleberg, Staffan (author)
- Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia / Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia / Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 639798, Singapore
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- Rice, Scott A. (author)
- Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia / Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia / Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 639798, Singapore
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(creator_code:org_t)
- Academic Press, 2012
- 2012
- English.
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In: Journal of Theoretical Biology. - : Academic Press. - 0022-5193 .- 1095-8541. ; 295, s. 23-36
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Biofilms are currently recognised as the predominant bacterial life-style and it has been suggested that biofilm development is influenced by a number of different processes such as adhesion, detachment, mass transport, quorum sensing, cell death and active dispersal. One of the least understood processes and its effects on biofilm development is cell death. However, experimental studies suggest that bacterial death is an important process during biofilm development and many studies show a relationship between cell death and dispersal in microbial biofilms. We present a model of the process of cell death during biofilm development, with a particular focus on the spatial localisation of cell death or cell damage. Three rules governing cell death or cell damage were evaluated which compared the effects of starvation, damage accumulation, and viability during biofilm development and were also used to design laboratory based experiments to test the model. Results from model simulations show that actively growing biofilms develop steep nutrient gradients within the interior of the biofilm that affect neighbouring microcolonies resulting in cell death and detachment. Two of the rules indicated that high substrate concentrations lead to accelerated cell death, in contrast to the third rule, based on the accumulation of damage, which predicted earlier cell death for biofilms grown with low substrate concentrations. Comparison of the modelling results with experimental results suggests that cell death is favoured under low nutrient conditions and that the accumulation of damage may be the main cause of cell death during biofilm development. (C) 2011 Elsevier Ltd. All rights reserved.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Biofilm
- Individual based CA
- Cell death
- Natural sciences
- Naturvetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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