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Association of cycl...
Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley : a high risk area
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- Hussain, Showket (author)
- Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India
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- M., Yuvaraj (author)
- Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India
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- Thakur, Nisha (author)
- Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India
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- Salam, Irfana (author)
- Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
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- Singh, Neha (author)
- Panjab University, Chandigarh, India
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- Mir, Mohammad Muzaffar (author)
- Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
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- Bhat, Mohammad Akbar (author)
- Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
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- Siddiqi, Mushtaq A. (author)
- Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India
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- Das, Bhudev C. (author)
- Dr. B.R. Ambedkar Research Centre for Biomedical Research (ACBR), University of Delhi, India
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- Bharadwaj, Mausumi (author)
- Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India
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(creator_code:org_t)
- 2011-01-25
- 2011
- English.
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In: Molecular Carcinogenesis. - : Wiley-Blackwell. - 0899-1987 .- 1098-2744. ; 50:7, s. 487-98
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Investigation of potential association of SNPs (G870A, rs9344; G1722C, rs678653) of cyclin D1 gene (CCND1) with susceptibility to esophageal squamous cell carcinoma (ESCC) in Kashmir valley (India). The study included 302 subjects comprising 151 ESCC cases and 151 controls. PCR-RFLP and direct sequencing were employed for genotyping. The G870A polymorphism, the individuals carrying GA + AA genotype was having 2.80-fold increased risk for development of ESCC (OR 2.8, 95% CI = 1.77-4.4; P = 0.0001) compared to GG genotype. Further a significantly higher risk was observed in individuals who consume >3 cups per day of salted tea (OR = 5.1; 95% CI = 1.6-16.7; P = 0.0016) and had smoking habits (OR = 6.3; 95% CI = 2.9-13.9; P = 0.0005). We also demonstrate for the first time in CCND1 1722 locus, the CC genotype was strongly associated with increased risk of developing ESCC (OR = 2.58; 95% CI = 1.61-4.15; P = 0.0001). In addition, the frequency of polymorphic C allele was also found to be higher in cases (OR = 1.92; 95% CI = 1.37-2.69; P = 0.0002). There appears to be an influence of CCND1 G870A/G1772C genotypes on genetic susceptibility to ESCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- CCND1
- esophageal cancer
- Kashmir; gene polymorphism
- Naturvetenskap
- Natural sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hussain, Showket
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M., Yuvaraj
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Thakur, Nisha
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Salam, Irfana
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Singh, Neha
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Mir, Mohammad Mu ...
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Bhat, Mohammad A ...
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Siddiqi, Mushtaq ...
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Das, Bhudev C.
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Bharadwaj, Mausu ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Molecular Carcin ...
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University of Skövde