Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population

Sobti, Ranbir ChanderDepartment of Biotechnology, Panjab University, 160014 Chandigarh, India (author)

Prostate cancer is the second most diagnosed cancer in men next to skin cancer in the developed world. Risk of disease varies most prominently with age, ethnicity, family history, and diet. Genetic polymorphism of some genes has been implicated in increasing the risk. The XPD (Xeroderma pigmentosum group D) gene codes for a DNA helicase involved in transcription and nucleotide excision repair. The aim of this study is to evaluate the effect of XPD 751 Lys/Gln polymorphism on risk of prostate cancer on north Indian patients. Blood sample from 150 prostate cancer patients, 150 from Prostate Hyper Plasia and equal number of samples from healthy control groups was collected from North India. The polymerase chain reaction and restrictive fragment length polymorphism techniques were implemented. Statistically non-significant increase risk of prostate cancer was observed with patients having Gln/Gln genotype (OR 1.62, 95% CI).

Berhane, NegaDepartment of Biotechnology, University of Gondar, Gondar, Ethiopia (author)
Melese, ShiferawDepartment of Mathematics, University of Gondar, Gondar, Ethiopia (author)
Mahdi, Salih AbdulDepartment of Biotechnology, Panjab University, 160014 Chandigarh, India (author)
Gupta, LibsyDepartment of Biotechnology, Panjab University, 160014 Chandigarh, India (author)
Thakur, HitenderDepartment of Biotechnology, Panjab University, 160014 Chandigarh, India (author)
Singh, NehaDepartment of Biotechnology, Panjab University, 160014 Chandigarh, India(Swepub:his)sinn (author)
Department of Biotechnology, Panjab University, 160014 Chandigarh, IndiaDepartment of Biotechnology, University of Gondar, Gondar, Ethiopia (creator_code:org_t)

In:Molecular and Cellular Biochemistry: Springer Science+Business Media B.V.362:1-2, s. 263-80300-81771573-4919

By the author/editor: Sobti, Ranbir Ch ...; Berhane, Nega; Melese, Shiferaw; Mahdi, Salih Abd ...; Gupta, Libsy; Thakur, Hitender; show more...; Singh, Neha; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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