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Differences in gene...
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Silventoinen, K.Departments of Social Research, Research Programs Unit, University of Helsinki, Helsinki, Finland; Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan
(author)
Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region : An individual-based pooled analysis of 40 twin cohorts
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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Oxford University Press,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:hj-36995
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-36995URI
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https://doi.org/10.3945/ajcn.117.153643DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59292URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-21868URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136350288URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m2)], but factors modifying these variance components are poorly understood.Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity.Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs).Results: The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 20-29 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI.Conclusions: The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.
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Jelenkovic, A.
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Sund, R.
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Yokoyama, Y.
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Hur, Y. -M
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Cozen, W.
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Hwang, A. E.
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Mack, T. M.
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Honda, C.
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Inui, F.
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Iwatani, Y.
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Watanabe, M.
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Tomizawa, R.
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Pietilainen, K. H.
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Rissanen, A.
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Siribaddana, S. H.
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Hotopf, M.
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Sumathipala, A.
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Rijsdijk, F.
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Tan, Q.
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Zhang, D.
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Pang, Z.
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Piirtola, M.Karolinska Institutet
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Aaltonen, S.
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Oncel, S. Y.
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Aliev, F.
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Rebato, E.
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Hjelmborg, J. B.
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Christensen, K.
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Skytthe, A.
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Kyvik, K. O.
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Silberg, J. L.
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Eaves, L. J.
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Cutler, T. L.
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Ordonana, J. R.
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Sanchez-Romera, J. F.
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Colodro-Conde, L.
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Song, Y. -M
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Yang, S.
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Lee, K.
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Franz, C. E.
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Kremen, W. S.
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Lyons, M. J.
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Busjahn, A.
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Nelson, T. L.
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Whitfield, K. E.
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Kandler, C.
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Jang, K. L.
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Gatz, M.
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Butler, D. A.
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Stazi, M. A.
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Fagnani, C.
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D'Ippolito, C.
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Duncan, G. E.
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Buchwald, D.
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Martin, N. G.
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Medland, S. E.
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Montgomery, G. W.
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Jeong, H. -U
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Swan, G. E.
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Krasnow, R.
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Magnusson, P. K. E.
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Pedersen, N. L.Karolinska Institutet
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Dahl Aslan, Anna K.,1975-Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Departments of Social Research, Research Programs Unit, University of Helsinki, Helsinki, Finland,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden ; Institute of Gerontology and Aging Research Network–Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Sweden(Swepub:his)dahb
(author)
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McAdams, T. A.
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Tuvblad, Catherine,1968-Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Department of Psychology, University of Southern California, Los Angeles CA, United States(Swepub:oru)ctd
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Gregory, A. M.
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Tynelius, P.Karolinska Institutet
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Baker, L. A.
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Tuvblad, C.
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Bayasgalan, G.
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Narandalai, D.
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Spector, T. D.
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Mangino, M.
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Lachance, G.
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Burt, S. A.
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Klump, K. L.
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Harris, J. R.
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Brandt, I.
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Nilsen, T. S.
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Krueger, R. F.
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McGue, M.
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Pahlen, S.
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Corley, R. P.
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Huibregtse, B. M.
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Bartels, M.
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Van Beijsterveldt, C. E. M.
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Willemsen, G.
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Goldberg, J. H.
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Rasmussen, F.
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Tarnoki, A. D.
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Tarnoki, D. L.
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Derom, C. A.
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Vlietinck, R. F.
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Loos, R. J. F.
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Hopper, J. L.
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Sung, J.
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Maes, H. H.
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Turkheimer, E.
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Boomsma, D. I.
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Sørensen, T. I. A.
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Kaprio, J.Departments of Public Health, Research Programs Unit, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine, Helsinki, Finland
(author)
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Karolinska InstitutetDepartments of Social Research, Research Programs Unit, University of Helsinki, Helsinki, Finland; Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan
(creator_code:org_t)
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In:American Journal of Clinical Nutrition: Oxford University Press106:2, s. 457-4660002-91651938-3207
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Silventoinen, K.
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Jelenkovic, A.
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Sund, R.
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Yokoyama, Y.
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Hur, Y. -M
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Cozen, W.
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show more...
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Hwang, A. E.
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Mack, T. M.
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Honda, C.
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Inui, F.
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Iwatani, Y.
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Watanabe, M.
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Tomizawa, R.
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Pietilainen, K. ...
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Rissanen, A.
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Siribaddana, S. ...
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Hotopf, M.
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Sumathipala, A.
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Rijsdijk, F.
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Tan, Q.
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Zhang, D.
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Pang, Z.
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Piirtola, M.
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Aaltonen, S.
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Oncel, S. Y.
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Aliev, F.
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Rebato, E.
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Hjelmborg, J. B.
-
Christensen, K.
-
Skytthe, A.
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Kyvik, K. O.
-
Silberg, J. L.
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Eaves, L. J.
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Cutler, T. L.
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Ordonana, J. R.
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Sanchez-Romera, ...
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Colodro-Conde, L ...
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Song, Y. -M
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Yang, S.
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Lee, K.
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Franz, C. E.
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Kremen, W. S.
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Lyons, M. J.
-
Busjahn, A.
-
Nelson, T. L.
-
Whitfield, K. E.
-
Kandler, C.
-
Jang, K. L.
-
Gatz, M.
-
Butler, D. A.
-
Stazi, M. A.
-
Fagnani, C.
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D'Ippolito, C.
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Duncan, G. E.
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Buchwald, D.
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Martin, N. G.
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Medland, S. E.
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Montgomery, G. W ...
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Jeong, H. -U
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Swan, G. E.
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Krasnow, R.
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Magnusson, P. K. ...
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Pedersen, N. L.
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Dahl Aslan, Anna ...
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McAdams, T. A.
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Tuvblad, Catheri ...
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Gregory, A. M.
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Tynelius, P.
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Baker, L. A.
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Tuvblad, C.
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Bayasgalan, G.
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Narandalai, D.
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Spector, T. D.
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Mangino, M.
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Lachance, G.
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Burt, S. A.
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Klump, K. L.
-
Harris, J. R.
-
Brandt, I.
-
Nilsen, T. S.
-
Krueger, R. F.
-
McGue, M.
-
Pahlen, S.
-
Corley, R. P.
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Huibregtse, B. M ...
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Bartels, M.
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Van Beijsterveld ...
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Willemsen, G.
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Goldberg, J. H.
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Rasmussen, F.
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Tarnoki, A. D.
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Tarnoki, D. L.
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Derom, C. A.
-
Vlietinck, R. F.
-
Loos, R. J. F.
-
Hopper, J. L.
-
Sung, J.
-
Maes, H. H.
-
Turkheimer, E.
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Boomsma, D. I.
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Sørensen, T. I. ...
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Kaprio, J.
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Örebro University
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