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Baseline telomere l...
Baseline telomere length and effects of a multidomain lifestyle intervention on cognition : The FINGER randomized controlled trial
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- Sindi, S. (author)
- Karolinska Institutet
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- Ngandu, T. (author)
- Karolinska Institutet
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- Hovatta, I. (author)
- Department of Biosciences, University of Helsinki, Helsinki, Finland
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- Kåreholt, Ingemar, 1960- (author)
- Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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- Antikainen, R. (author)
- Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
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- Hänninen, T. (author)
- Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland
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- Levälahti, E. (author)
- Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
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- Laatikainend, T. (author)
- Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
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- Lindström, J. (author)
- Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
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- Paajanen, T. (author)
- Institute of Occupational Health, Helsinki, Finland
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- Peltonen, M. (author)
- Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
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- Khalsa, D. S. (author)
- Department of General Internal Medicine, Geriatrics and Integrative Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
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- Wolozin, B. (author)
- Departments of Pharmacology and Neurology, Boston University School of Medicine, Boston, MA, USA
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- Strandberg, T. (author)
- Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
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- Tuomilehto, J. (author)
- Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
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- Soininen, H. (author)
- Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland
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- Kivipelto, M. (author)
- Karolinska Institutet
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- Solomon, A. (author)
- Karolinska Institutet
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(creator_code:org_t)
- IOS Press, 2017
- 2017
- English.
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In: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 59:4, s. 1459-1470
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https://hj.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60-77 years identified from the general population. Participants were randomly assigned to the lifestyle intervention (diet, exercise, cognitive training, and vascular risk management) and control (general health advice) groups. Primary outcome was change in cognition (comprehensive neuropsychological test battery). Secondary outcomes were changes in cognitive domains: Memory, executive functioning, and processing speed. 775 participants (392 control, 383 intervention) had baseline LTL (peripheral blood DNA). Mixed effects regression models with maximum likelihood estimation were used to analyze change in cognition as a function of randomization group, time, baseline LTL, and their interaction. Intervention and control groups did not significantly differ at baseline. Shorter LTL was related to less healthy baseline lifestyle. Intervention benefits on executive functioning were more pronounced among those with shorter baseline LTL (p-value for interaction was 0.010 adjusted for age and sex, and 0.007 additionally adjusted for baseline lifestyle factors). The FINGER intervention cognitive benefits were more pronounced with shorter baseline LTL, particularly for executive functioning, indicating that the multidomain lifestyle intervention was especially beneficial among higher-risk individuals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Cognition
- dementia
- lifestyle
- multidomain intervention
- telomere length
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Sindi, S.
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Ngandu, T.
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Hovatta, I.
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Kåreholt, Ingema ...
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Antikainen, R.
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Hänninen, T.
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show more...
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Levälahti, E.
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Laatikainend, T.
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Lindström, J.
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Paajanen, T.
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Peltonen, M.
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Khalsa, D. S.
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Wolozin, B.
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Strandberg, T.
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Tuomilehto, J.
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Soininen, H.
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Kivipelto, M.
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Solomon, A.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Jönköping University
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Karolinska Institutet