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Overweight and obes...
Overweight and obesity impair left ventricular systolic function as measured by left ventricular ejection fraction and global longitudinal strain
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- Blomstrand, Peter (author)
- Jönköping University,HHJ, Avdelningen för klinisk diagnostik,HHJ. Biomedicinsk plattform,County Hospital Ryhov, Department of Clinical Physiology, Jönköping, Sweden,Cty Hosp Ryhov, Sweden; Jonkoping Univ, Sweden
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- Sjöblom, Peter (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten
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- Nilsson, Mats (author)
- Futurum, Academy for Health and Care, Jönköping, Sweden
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- Wijkman, Magnus (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN
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- Engvall, Martin (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Länne, Toste (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland
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- Nyström, Fredrik H (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
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- Östgren, Carl Johan, 1963- (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Vårdcentralen Ödeshög
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- Engvall, Jan (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US
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(creator_code:org_t)
- 2018-08-14
- 2018
- English.
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In: Cardiovascular Diabetology. - : BioMed Central. - 1475-2840. ; 17:1
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Abstract
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- AimsObesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim of the study was to explore the effects of overweight and obesity on left ventricular systolic function in patients with type 2 diabetes mellitus and a control group of non-diabetic persons.MethodsWe prospectively investigated 384 patients with type 2 diabetes mellitus, and 184 controls who participated in the CARDIPP and CAREFUL studies. The participants were grouped according to body mass index (normal weight < 25 kg/m2, overweight 25–29 kg/m2, and obesity ≥ 30 kg/m2). Echocardiography was performed at the beginning of the study and after 4-years in the patient group.ResultsUnivariable and multivariable regression analysis revealed that variations in left ventricular ejection fraction, global longitudinal strain, left ventricular mass and diastolic function expressed as E/é (the ratio between early diastolic mitral flow and annular motion velocities) all are related to body mass index. The mean and standard deviation of left ventricular ejection fraction and global longitudinal strain values were 57% (8%) vs. − 18.6% (2.3%) for normal weight patients, 53% (8%) vs. − 17.5% (2.3%) for overweight, and 49% (9%) vs. − 16.2% (3.0%) for obese (p < 0.05 vs. p < 0.05). Corresponding results in the control group were 58% (6%) vs. − 22.3% (3.0%), 55% (7%) vs. − 20.8% (3.1%) and 54% (8%) − 19.6% (4.0%) (p < 0.05 vs. p < 0.05). Patients who gained weight from baseline to follow-up changed left ventricular ejection fraction (median and interquartile range) by − 1.0 (9.0) % (n = 187) and patients who lost weight changed left ventricular ejection fraction by 1.0 (10.0) % (n = 179) (p < 0.05).ConclusionOverweight and obesity impair left ventricular ejection fraction and global longitudinal strain in both patients with type 2 diabetes mellitus and non-diabetic persons.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Diabetes mellitus
- Echocardiography
- Obesity
- Overweight
Publication and Content Type
- ref (subject category)
- art (subject category)
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