Individual genetic variation might predict acute skin reactions in women undergoing adjuvant breast cancer radiotherapy

• Adverse skin reactions during radiotherapy (RT) are common. The aim of this study was to explore whether genetic variation might be linked to acute radiation skin reactions (ARSR). Materials and Methods: One hundred and nineteen women undergoing adjuvant RT for breast cancer were included. The symptoms of itching, burning and irritation were self-reported twice using the visual analogue scale. Assessments used the Radiation Therapy Oncology Group scoring system for acute RT skin reaction (RTOG scale). Blood-based single nucleotide polymorphism (SNP) analysis was performed. Thirty SNPs of well-defined functional genes were investigated. Results: All women were assessed with ARSR. After RT, the women self-reported itching (n=97), burning (n=64) and irritation (n=96). Two SNPs in X-Ray Repair Cross Complementing 2 gene (XRCC2) rs2040639 and interferon gamma (IFNG) rs2069705 genes were found to be associated with ARSR. Conclusion: An association between two SNPs and ARSR was found. The possibility of using these SNPs as prognostic biomarkers for ARSR as tools to improve the care of patients needs further investigation. 

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Breast cancer

Radiotherapy

Single nucleotide polymorphism

Skin reactions

cyclophosphamide

epirubicin

fluorouracil

gamma interferon

xeroderma pigmentosum group D protein

DNA binding protein

IFNG protein

human

tumor marker

XRCC2 protein

human

adjuvant radiotherapy

adult

Article

cancer prognosis

cohort analysis

female

gene function

genetic association

genetic variation

human

middle aged

partial mastectomy

priority journal

radiation dermatitis

scoring system

self report

skin burning sensation

skin irritation

skin pruritus

acute disease

aged

breast tumor

dna mutational analysis

genetic predisposition

genetics

prognosis

very elderly

Aged

80 and over

Biomarkers

Tumor

Breast Neoplasms

Cohort Studies

DNA-Binding Proteins

Genetic Predisposition to Disease

Humans

Interferon-gamma

Polymorphism

Single Nucleotide

Radiodermatitis

Radiotherapy

Adjuvant

Publication and Content Type

ref (subject category)

art (subject category)