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Individual genetic ...
Individual genetic variation might predict acute skin reactions in women undergoing adjuvant breast cancer radiotherapy
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- Oliva, Delmy, 1967- (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Department of Oncology, Ryhov County Hospital, Jönköping, Sweden
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- Nilsson, Mats (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten,Futurum-The Academy for Healthcare, Region Jönköping County, Jönköping, Sweden
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- Strandéus, Michael (author)
- Department of Oncology, Ryhov County Hospital, Jönköping, Sweden
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- Andersson, Bengt-Åke (author)
- Linköpings universitet,Jönköping University,HHJ. Biomedicinsk plattform,Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; and Department of Laboratory medicine, Region Jönköping County, Jönköping, Sweden,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten
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- Sharp, Lena (author)
- Regional Cancer Centre, Stockholm-Gotland, Stockholm, Sweden / Department of Learning, Informatics, Management and Ethics, Karolinska Institute, Stockholm, Sweden
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- Lewin, Nongnit (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Department of Laboratory medicine, Region Jönköping County, Jönköping, Sweden
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- Lewin, Freddi (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Department of Oncology, Ryhov County Hospital, Jönköping, Sweden
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(creator_code:org_t)
- 2018-11-30
- 2018
- English.
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In: Anticancer Research. - : International Institute of Anticancer Research. - 0250-7005 .- 1791-7530. ; 38:12, s. 6763-6770
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Abstract
Subject headings
Close
- Adverse skin reactions during radiotherapy (RT) are common. The aim of this study was to explore whether genetic variation might be linked to acute radiation skin reactions (ARSR). Materials and Methods: One hundred and nineteen women undergoing adjuvant RT for breast cancer were included. The symptoms of itching, burning and irritation were self-reported twice using the visual analogue scale. Assessments used the Radiation Therapy Oncology Group scoring system for acute RT skin reaction (RTOG scale). Blood-based single nucleotide polymorphism (SNP) analysis was performed. Thirty SNPs of well-defined functional genes were investigated. Results: All women were assessed with ARSR. After RT, the women self-reported itching (n=97), burning (n=64) and irritation (n=96). Two SNPs in X-Ray Repair Cross Complementing 2 gene (XRCC2) rs2040639 and interferon gamma (IFNG) rs2069705 genes were found to be associated with ARSR. Conclusion: An association between two SNPs and ARSR was found. The possibility of using these SNPs as prognostic biomarkers for ARSR as tools to improve the care of patients needs further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast cancer
- Radiotherapy
- Single nucleotide polymorphism
- Skin reactions
- cyclophosphamide
- epirubicin
- fluorouracil
- gamma interferon
- xeroderma pigmentosum group D protein
- DNA binding protein
- IFNG protein
- human
- tumor marker
- XRCC2 protein
- human
- adjuvant radiotherapy
- adult
- Article
- cancer prognosis
- cohort analysis
- female
- gene function
- genetic association
- genetic variation
- human
- middle aged
- partial mastectomy
- priority journal
- radiation dermatitis
- scoring system
- self report
- skin burning sensation
- skin irritation
- skin pruritus
- acute disease
- aged
- breast tumor
- dna mutational analysis
- genetic predisposition
- genetics
- prognosis
- very elderly
- Aged
- 80 and over
- Biomarkers
- Tumor
- Breast Neoplasms
- Cohort Studies
- DNA-Binding Proteins
- Genetic Predisposition to Disease
- Humans
- Interferon-gamma
- Polymorphism
- Single Nucleotide
- Radiodermatitis
- Radiotherapy
- Adjuvant
Publication and Content Type
- ref (subject category)
- art (subject category)
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