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Individual genetic ...
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Oliva, Delmy,1967-Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Department of Oncology, Ryhov County Hospital, Jönköping, Sweden
(author)
Individual genetic variation might predict acute skin reactions in women undergoing adjuvant breast cancer radiotherapy
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-11-30
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International Institute of Anticancer Research,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:hj-42804
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-42804URI
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https://doi.org/10.21873/anticanres.13047DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139770459URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153515URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Uppsala University; Knut & Alice Wallenberg Foundation of Uppsala, Sweden; Foundation for Clinical Cancer Research in Jonkoping; Futurum Academy for Health and Care, Region Jonkoping County, Sweden; FORSS-Medical Research Council of Southeast Sweden
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Adverse skin reactions during radiotherapy (RT) are common. The aim of this study was to explore whether genetic variation might be linked to acute radiation skin reactions (ARSR). Materials and Methods: One hundred and nineteen women undergoing adjuvant RT for breast cancer were included. The symptoms of itching, burning and irritation were self-reported twice using the visual analogue scale. Assessments used the Radiation Therapy Oncology Group scoring system for acute RT skin reaction (RTOG scale). Blood-based single nucleotide polymorphism (SNP) analysis was performed. Thirty SNPs of well-defined functional genes were investigated. Results: All women were assessed with ARSR. After RT, the women self-reported itching (n=97), burning (n=64) and irritation (n=96). Two SNPs in X-Ray Repair Cross Complementing 2 gene (XRCC2) rs2040639 and interferon gamma (IFNG) rs2069705 genes were found to be associated with ARSR. Conclusion: An association between two SNPs and ARSR was found. The possibility of using these SNPs as prognostic biomarkers for ARSR as tools to improve the care of patients needs further investigation.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
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Breast cancer
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Radiotherapy
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Single nucleotide polymorphism
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Skin reactions
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cyclophosphamide
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epirubicin
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fluorouracil
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gamma interferon
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xeroderma pigmentosum group D protein
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DNA binding protein
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IFNG protein
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human
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tumor marker
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XRCC2 protein
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human
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adjuvant radiotherapy
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adult
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Article
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cancer prognosis
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cohort analysis
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female
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gene function
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genetic association
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genetic variation
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human
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middle aged
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partial mastectomy
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priority journal
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radiation dermatitis
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scoring system
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self report
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skin burning sensation
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skin irritation
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skin pruritus
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acute disease
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aged
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breast tumor
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dna mutational analysis
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genetic predisposition
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genetics
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prognosis
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very elderly
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Aged
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80 and over
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Biomarkers
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Tumor
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Breast Neoplasms
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Cohort Studies
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DNA-Binding Proteins
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Genetic Predisposition to Disease
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Humans
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Interferon-gamma
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Polymorphism
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Single Nucleotide
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Radiodermatitis
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Radiotherapy
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Adjuvant
Added entries (persons, corporate bodies, meetings, titles ...)
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Nilsson, MatsLinköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten,Futurum-The Academy for Healthcare, Region Jönköping County, Jönköping, Sweden(Swepub:liu)matni75
(author)
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Strandéus, MichaelDepartment of Oncology, Ryhov County Hospital, Jönköping, Sweden
(author)
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Andersson, Bengt-ÅkeLinköpings universitet,Jönköping University,HHJ. Biomedicinsk plattform,Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; and Department of Laboratory medicine, Region Jönköping County, Jönköping, Sweden,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten(Swepub:liu)benan04
(author)
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Sharp, LenaRegional Cancer Centre, Stockholm-Gotland, Stockholm, Sweden / Department of Learning, Informatics, Management and Ethics, Karolinska Institute, Stockholm, Sweden
(author)
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Lewin, NongnitLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Department of Laboratory medicine, Region Jönköping County, Jönköping, Sweden(Swepub:liu)nonle33
(author)
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Lewin, FreddiLinköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Department of Oncology, Ryhov County Hospital, Jönköping, Sweden(Swepub:liu)n/a
(author)
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Linköpings universitetAvdelningen för Kirurgi, Ortopedi och Onkologi
(creator_code:org_t)
Related titles
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In:Anticancer Research: International Institute of Anticancer Research38:12, s. 6763-67700250-70051791-7530
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